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Endocrine Abstracts (2016) 44 EP86 | DOI: 10.1530/endoabs.44.EP86

SFEBES2016 ePoster Presentations (1) (116 abstracts)

Central autonomization of peripheral precocious puberty

Belazzouz Abderahmen Youssouf



Introduction

The precocious puberty defines itself by the appearance of secondary sexual characters before the age of 9 years at the boy.

We bring back the case of a precocious pseudo puberty iso sexual having evolved towards a central precocious puberty revealed by in an advance of secondary bony age in a delay of diagnosis.

Observation: It is about a child masculine sex of 6-year-old and 11 month without personal.


Introduction

The precocious puberty defines itself by the appearance of secondary sexual characters before the age of 9 years at the boy.

We bring back the case of a precocious pseudo puberty iso sexual having evolved towards a central precocious puberty revealed by in an advance of secondary bony age in a delay of diagnosis.

ATCD, accepted for reappraisal of a precocious pseudo puberty linked to a bilateral testicular increase of measuring volume between 6–8 ml a stadium of Tanner G2P3, associate in d ’ other signs of hyper androgénie such as of the acne, a husky voice, a wingspan android, a staturale advance (3DS) and weight with BMI in 24 kg/m2 as well as bony age of 13 years and 1/2 is. This in spite of a treatment freinateur by Déxaméthasone 0.25 mg/j, Acetate of cyprotérone 25 mg/j, hydrocortisone 10 mg/j.

On biological plan: ACTH: 44 pg/ml 17 (oh) p: 0.55 ng/ml.

FSH: 2.34 LH: 1.94 mui/ml Testo: 1.72 nmol/l (0.1–1.12).

Scrotal ultrasound scan confirmed the increase of volume of the 2 testicles in 30 mm (6 ml) while eliminating the presence of surrénaliennes testicular inclusions.

Conclusion: The precocious pseudo puberty by block in 21 hydroxylase virilisante pure secondary form in a mutation I172N which represents 33% of classical forms, can autonomiser especially in case of diagnostic delay and as a result, an advance of bony age by leading a central ripening of Gonadostat can trigger off a central puberty.

This motivated a treatment of our patient by Décapeptyl 1ampoule/month.

Volume 44

Society for Endocrinology BES 2016

Brighton, UK
07 Nov 2016 - 09 Nov 2016

Society for Endocrinology 

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