ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2016) 44 S5.2 | DOI: 10.1530/endoabs.44.S5.2

Vitamin D and brain development

Darryl Eyles1,2

1QBI University of Qld, Brisbane, Qld, Australia; 2QCMHR University of Qld, Brisbane, Qld, Australia.

I have established that low levels of vitamin D at birth increase the risk of schizophrenia in later life in two independent large Danish case/control studies. I have also shown such exposures are associated with increased rates of autism in a large Dutch general population cohort. I have developed an animal model of Developmental Vitamin D (DVD) deficiency which produces phenotypes that mimic many of the symptoms of schizophrenia. In our latest study we have shown the hormonally active form of vitamin D abolishes all phenotypes in a leading inflammatory animal model of relevance to autism.

In this talk I will discuss our extensive data that indicates optimal vitamin D status is required for normal healthy brain development. The evidence obtained from our epidemiological studies is convergent with data obtained from our preclinical and cellular models indicating vitamin D is a powerful developmental neurosteroid. In the absence of this steroid, brain ontogeny is irreversibly affected leading to permanent molecular, cellular and functional brain abnormalities.

Article tools

My recent searches

No recent searches.

My recently viewed abstracts