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Endocrine Abstracts (2017) 49 EP239 | DOI: 10.1530/endoabs.49.EP239

1Department of Endocrinology, Diabetes and Metabolism, Red Cross General Hospital, Athens, Greece; 2Infectious Diseases Unit, Red Cross General Hospital, Athens, Greece.

Objective: To investigate endocrine disorders concerning bone metabolism, thyroid and gonadal axis in treatment–naïve HIV-infected male patients.

Subjects and methods: We studied 70 male, treatment-naïve patients (stage A=60, stage B=10) from the Infectious Diseases Unit of our Hospital. Anthropometric indices were measured and BMI was calculated for each participant. Blood samples were obtained after an overnight fasting for the evaluation of thyroid hormones, 25OHD3, gonadotropins, total testosterone, sex hormone binding globulin (SHBG) levels. Free Androgen Index (FAI) and bioavailable testosterone (BAT) were calculated. Bone mineral density (BMD) in the lumbar spine and adipose tissue percentage (FMR) was measured with DEXA. SPSS 16.0 was used for statistical data processing.

Results: Patients were 33.7±8.9 years old (mean±S.D.), BMI was 24.6±5.2 kg/m2, CD4+ were 475 c/μl (24–1,476) and viral load was 38 600 cp/ml (927–422 000). Four patients (6%) presented with low testosterone levels (hypogonadotropic hypogonadism) and one with newly diagnosed subclinical hypothyroidism requiring therapy. Significant reduction of BMD was observed in 26 patients (37%) from which 22 had osteopenia (Z score −1 to −2.5) and four had osteoporosis (Z score <−2.5). Reduced BMD correlated positively with low BMI (P<0.01), while no correlation was found with viral load, CD4+, smoking, 25OHD3 and gonadal hormones’ concentrations (P>0.05).

Conclusion: In treatment – naïve HIV-infected male patients, the most frequently observed endocrine disorder is reduced BMD, which does not seem to correlate with HIV infection markers. In patients with low BMI, measurement of BMD would be helpful for early diagnosis of reduced bone mass and the prevention of further loss by using the most suitable antiretroviral therapy.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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