Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2017) 49 S28.3 | DOI: 10.1530/endoabs.49.S28.3

ECE2017 Symposia Sleep, love and reproduction (Endorsed by Endocrine Connections) (3 abstracts)

Kisspeptin and neurokinin B – novel reproductive hormones with therapeutic potential

Waljit Dhillo


Kisspeptin and neurokinin B are 2 novel key hypothalamic hormones which are vital in normal reproductive function. Inactivating mutations for the gene or the receptor for either of these peptides will cause a failure of puberty due to hypogonadtotrophic hypogondaism. In this talk I will present evidence to suggest that kisspeptin is important in sexual and emotional processing in humans (1). In addition I will present evidence which suggests that NK3R (the receptor for NKB in humans) is important as a mediator of menopausal flushing and this has potentially practice changing therapeutic potential (2).


1. Comninos AN, et al. Kisspeptin modulates sexual and emotional brain processing in humans. J Clin Invest. 2017 127 709–719.

2. Comninos AN, et al. Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet online on 3rd April 2017

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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