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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Eposter Presentations: Calcium and Bone

Clinical case reports - Thyroid/Others

ea0049ep315 | Clinical case reports - Thyroid/Others | ECE2017

An unique case of celiac disease with hypocoagulation and secondary hyperparathyreodism in elderly patient – a case report

Barbakadze Gocha , Tigishvili Lali , Ramishvili Levan , Tsikarishvili Nani , Burnadze Koba

Introduction: Celiac disease (CD) an autoimmune disorder of the small intestine, was considered as a disease of childhood. The symptoms can be obvious. That is the main reason why CD is underdiagnosed in elderly patients.Aims & Methods: The purpose of our study was to demonstrate a clinical case of CD which was diagnosed in a 41-year-old female patient. The patient attended our clinic with complains of weakness, tenderness, abdominal distension, weig...

ea0049ep316 | Clinical case reports - Thyroid/Others | ECE2017

Optic neuritis as presenting complaint in primary hypoparathyroidism

Fahad Arshad Muhammad , Kang Steven , Arif Jadoon Nauman , Karim Rehmat

Background: Papilledema and raised intracranial pressure has been reported frequently in patients with hypoparathyroidism but very rarely optic neuritis (1).Clinical case: We report a case of 63-year-old male who presented to ophthalmology with right-sided visual loss and a relative afferent pupillary defect. He was diagnosed with optic neuritis and underwent MRI brain which showed bilateral white matter changes with the possibility of demyelination. He ...

ea0049ep317 | Clinical case reports - Thyroid/Others | ECE2017

The parathyroid carcinoma in a young adult male

Nur Firat Sevde , Karaca Anara , Colak Bozkurt Nujen , Unverdi Hatice

Introduction: Parathyroid carcinoma is a rare malignancy of the parathyroid glands. Parathyroid carcinoma may be suspected, but it usually cannot be confirmed prior to operation.Case: A 35-year-old male was consulted to Endocrinology department with persistant kidney stones. He was operated five times in 10 years for recurrent kidney stones.His lab results are as follows; Ca:13(8.8–10.6), P:2.2 mg/dl(2.5–4.5), ALP:84U/L(3...

ea0049ep318 | Clinical case reports - Thyroid/Others | ECE2017

Clinical case of atypical parathyroid adenoma with severe hypercalcemia and multiple fragility fractures

Eremkina Anna , Mokrysheva Natalia , Krupinova Julia , Mirnaya Svetlana , Voronkova Iya

Introduction: Atypical parathyroid adenoma (APA) is rarely encountered cause of primary hyperparathyroidism (PHPT). No definite criteria are considered to distinguish preoperatively APA from parathyroid typical adenoma or carcinoma.The aimTo describe the clinical course of a patient with an atypical parathyroid adenoma with severe hypercalcemia and multiple fragility fractures.Case presentation: A 61-year-old...

ea0049ep319 | Clinical case reports - Thyroid/Others | ECE2017

Congenital fibrous dysplasia and Klinefelter syndrome: coincidence or not?

Grama Maria Alexandra , Dumitrache Constantin

Congenital fibrous dysplasia is a rare disease with a broad spectrum of manifestations, including various endocrinopathies;precocious puberty, hyperthyroidism, excess growth hormone, hypophosphatemia mediated by FGF23.We present the case of a 33 year old male, who presented in our endocrinology service with infertility and bone pain. He was diagnosed at the age of years old with congenital fibrous dyplasia and suffered multiple surgeries for bone decompr...

ea0049ep320 | Clinical case reports - Thyroid/Others | ECE2017

Parathyroid nodular hyperplasia: when imaging exams fail

Osorio Ana Sofia , Rocha Jose , Faria Carolina , Barbosa David , Nobre Ema , Bugalho Maria Joao

Introduction: Parathyroid hyperplasia is the second cause of primary hyperparathyroidism (PH), representing 15–20% of all cases. The scintigraphy with Tc-99m-Sestamibi is a preoperative exam used to identify parathyroid adenomas or hyperplasia. It has a sensibility of 50–90%, which increases with larger parathyroid size. The neck ultrasonography (US) has also an important role detecting parathyroid enlarged glands with 70% sensibility. We report a case of parathyroid...

ea0049ep321 | Clinical case reports - Thyroid/Others | ECE2017

As clear as mud: an atypical case of primary hyperparathyroidism

Lai Jessica , Niles Navin , Lau Namson

Objective: A young woman presented with marked hyperparathyroidism with post-operative course complicated by hungry bone syndrome and diagnostic and management challenges of ongoing hypocalcaemia with hyperparathyroidism.Method: ML, a 32-year-old Fijian Indian female, was referred with severe hypercalcaemia, following one-year history of migratory debilitating bone pain. Initial labs showed corrected calcium (C.Ca) 3.17 [2.10–2.60 mmol/l], parathyro...

ea0049ep322 | Clinical case reports - Thyroid/Others | ECE2017

Familial hypocalciuric hypercalcemia with a new heterozygous missense mutation of CaSR gene and cinacalcet treatment

Kiyici Sinem , Uygun Burcin , Gorukmez Orhan

Introduction: Familial hypocalciuric hypercalcemia (FHH) is an autosomal-dominant genetic disease caused by an inactivating mutation in the gene encoding the calcium sensing receptor (CaSR). The loss of function leads to increased circulating level of PTH and subsequent hypercalcemia.Case report: 20-year-old male patient referred to our center with hypercalcemia which was found after the syncope. His serum calcium level was 11.7 mg/dl and the phosphorus ...

ea0049ep323 | Clinical case reports - Thyroid/Others | ECE2017

Parathyroid carcinoma can be misdiagnosis with medullary thyroid cancer: how is that possible?

Mokrysheva Natalia , Krupinova Julia , Pigarova Ekaterina , Platonova Nadezhda , Voronkova Iya , lanschakov Kirill

Background: Hypercalcemia may stimulate thyroid’s C-cells to produce the calcitonin, that could lead to misdiagnosis of medullary thyroid cancer.Clinical case: A 47-year-old woman suffered from fracture of the left knee. She could not walk and used a wheelchair. CT scan in a public hospital detected multiple bone lytic changes in the ribs and vertebrae (mts?), tumor in the liver (mts?) and node in the thyroid gland 2.6*1.9 cm. Thyroid biopsy showed ...

ea0049ep324 | Clinical case reports - Thyroid/Others | ECE2017

Clinical case of pachydermoperiostosis

Karimova Munira , Khalimova Zamira

The aim: To study the case of Pachydermoperiostosisis.Material and methods: We report a case of a 24-year old male complaining of marked changes in appearance due to the disfiguring thickening and wrinkling of skin, excessive greasiness and perspiration, marked horizontal creases on the forehead, with deep furrows between them, increase in the thickness of eye lids, “senile expression” of the face, thickening of distal parts of extremities, fin...

ea0049ep325 | Clinical case reports - Thyroid/Others | ECE2017

Vascular dementia in a 57-year old woman with adenoma of parathyroid gland

Hodzic Mubina

Dementia describes a set of symptoms such as memory loss, difficulties with thinking, problem solving or language. Vascular dementia is a second most common type of dementia, rare under 65 year old. I report a case of 57- year-old woman with diagnosed dementia vascularis in Neurology department. Beside neurological diagnostic methods(brain scan-CT, MRI, Color Doppler of carotids, she had hypercalcaemia (2.96–3.04 mmol/l; normal range 2.20–2.60) as high calciuresis/24...

ea0049ep326 | Clinical case reports - Thyroid/Others | ECE2017

Equivocal preoperative imaging including 18F-fluorocholine PET-CT in primary hyperparathyroidism and nodular thyroid disease – case report

Zajickova Katerina

66-year old woman came first for an evaluation of nodular thyroid disease. Primary hyperparathyroidism (PHPT) was incidentally diagnosed during the entrance lab test with total calcium 2.62 mmol/l and PTH 93 ng/l. Serum creatinine was normal and 25 OH vitamin D was 97 nmol/l. Dual-energy X-ray absorptiometry was carried out and revealed osteoporosis at lumbar spine. Moreover, there were two low-trauma fractures in a recent patient history. Although hypercalcemia was mild, the ...

ea0049ep327 | Clinical case reports - Thyroid/Others | ECE2017

Parathyroid carcinoma: a report of cases

Unsal İlknur Ozturk , Cakal Erman , Ucan Bekir , Calıskan Mustafa , Tutal Esra , Karakose Melia , Arslan Muyesser Sayki , Ozbek Mustafa

Background: Primary hyperparathyroidism (PHPT) is one of the most common endocrine diseases. Parathyroid carcinoma, a rare entity, comprises a small percentage of patients with hyperparathyroidism and represents 0.005% of all cancers and <1% of cases of PHPT.Material and methods: Patients was diagnosed at the Endocrinology Department of Diskapi Yildirim Beyazit Training and Research Hospital between 2010 and 2016. Ultrasound and 99mTc-Sestamibi confi...

ea0049ep328 | Clinical case reports - Thyroid/Others | ECE2017

A rare case of giant parathyroid adenoma: diagnostic and therapeutic aspects

Silaghi Cristina Alina , Silaghi Horatiu , Cobzac Gheorghe , Encică Svetlana , Rădi Romina Alina , Cosma Daniel Tudor , Ciurea Anca , Georgescu Carmen Emanuela

Parathyroid adenomas (85% of cases of primary hyperparathyroidism) are usually small in size (weigh 70 mg – 1 g). Giant parathyroid adenomas (GPTA) weighing more than 3.5 g are very rare, more common in males, in the 6th decade of life, generally affect one parathyroid gland, are oxyphilic and ectopic in 50% of cases.We report the case of a 53-year-old woman presented for asthenia, fatigue, tingling in the arms and legs without other symp...

ea0049ep329 | Clinical case reports - Thyroid/Others | ECE2017

Autosomal dominant hypocalcemia in a Portuguese family: novel mutation in the calcium-sensing receptor gene

Gomes Vania , Ferreira Florbela , Silvestre Catarina , Castro Raquel , Joao Bugalho Maria

Introduction: Autosomal dominant hypocalcemia (ADH) is a rare condition, caused by activating mutations in the calcium-sensing receptor (CASR) gene. Affected individuals have hypocalcemia with inappropriately low parathyroid hormone (PTH) levels.Case report: A 50-year-old woman, asymptomatic, was referred to our Endocrinology department for investigation of hypocalcemia detected in routine blood analysis (serum corrected calcium was 7.4 mg/dl &#...

ea0049ep330 | Clinical case reports - Thyroid/Others | ECE2017

A case of intrathyroidal parathyroid adenoma presented with severe 25(OH)D3 deficiency, bone pain and high PTH

Topaloglu Omercan , Evren Bahri , Sahin Ibrahim , Unal Bulent

The most frequent pathology of primary hyperparathyroidism presented with the findings of hypercalcemia is parathyroid adenoma. Some patients having the signs of primary hyperparathyroidism may have intrathyroidal parathyroid adenoma and it may be overlooked. We present a case of intrathyroidal parathyroid adenoma presented with bone pain.47-year-old female patient referred to our clinics with bone pain and she had no pruritus, dry mouth, dyspepsia, abdo...

ea0049ep331 | Clinical case reports - Thyroid/Others | ECE2017

The rare cause of primary hyperparathyroidism: Parathyroid Carcinoma

Bestepe Nagihan , Ozdemir Didem , Polat Sefika Burcak , Evranos Berna , Ersoy Reyhan , Cakir Bekir

Introduction: Parathyroid carcinoma (PC) is a rare endocrine malignancy which accounts for 0.005% of all cancers and less than 1% of primary hyperparathyroidism cases. This uncommon tumor usually occurs during the fifth decade of life, with equal frequency in both sexes, and has an indolent but progressive course. It’s frequently symptomatic and patients may have high values of serum calcium and parathyroid hormone (PTH) with a palpable cervical mass. PC generally occurs ...

ea0049ep332 | Clinical case reports - Thyroid/Others | ECE2017

A parathyroid adenoma presented with diffuse bone lesions and anemia

Kok Irem , Dogan Fatma , Cander Soner , Gul Ozen Oz , Erturk Erdinc , Ersoy Canan

Primary Hyperparathyroidism is a common endocrine disorder characterized with high parathyroid hormone (PTH) and calcium (Ca) levels. Although most of the patients are asymptomatic, some patients may be presented with renal, gastrointestinal, musculoskeletal, neurologic or cardiovascular signs associated with hypercalcemia or elevated parathyroid hormone related findings such as bone disease, nephrolithiasis, hypophosphatemia increased production of calcitriol, hypomagnesemia,...

ea0049ep333 | Clinical case reports - Thyroid/Others | ECE2017

Common bone lesions may be a sign of parathyroid carcinoma in the primary hyperparathyroidism

Cander Soner , Gul Ozen Oz , Sisman Pinar , Ersoy Canan

A 60-year-old male patient who presented with left hip and knee pain was found to be compatible with primary hyperparathyroidism (PTH:2233 pg/ml, calcium: 15.7 mg/dl, phosphorus: 2.9 mg/dl creatinin:1.99 mg/dl, 25-OH-D:9.7 μg/l, ALP:532 mU/ml). Bone grafts of the patient showed multiple lytic lesions in the pelvis, cranium and long-bones. Neck ultrasonography showed hypoechoic solid nodule with cystic areas, 2×2 cm with size in the left thyroid gland inferior region ...

ea0049ep334 | Clinical case reports - Thyroid/Others | ECE2017

Broken bones and blindness- a rare cause of osteoporosis

Sagar Rebecca , Abbas Afroze

Case History: A 37 year-old gentlemen was referred to metabolic bone clinic due to recurrent recent fragility fractures. He had several fractures throughout childhood, and these had continued to occur into his adult life. He was blind in his left eye since birth. He felt that this had contributed to his fractures, due to falls. There had been no other previous major health problems. His brother had a similar eye condition. There were no other risk factors for osteoporosis. The...

ea0049ep335 | Clinical case reports - Thyroid/Others | ECE2017

An usual cause of post operative hypocalcemia

Mnif Fatma , Safi Wajdi , Rekik Nabila , Mrabet Houcem , Elfekih Hamza , Charfi Nadia , Mnif Mouna , Abid Mohammed

Introduction: The otorhinolaryngologist can be confronted to multiple surprises after a thyroid surgeryCase description: We report the case of a 48 year-old woman admitted with post operative hypocalcaemia (after thyroidectomy?). The patient has a history of hypothyroidism since 5 years. She then presented a cervical swelling. The ultra-sound confirmed the presence of a suspicious thyroid nodule measuring 4 cm. A thyroidectomy was then conducted. Post op...

ea0049ep336 | Clinical case reports - Thyroid/Others | ECE2017

Brown tumor in a normocalcemic patient

Sisman Pinar , Gul Ozen Oz , Cander Soner , Erturk Erdinc , Ersoy Canan

Background: Brown tumor of bone is a non-neoplastic lesion resulting from abnormal bone metabolism in hyperparathyroidism. Brown tumor, as the only and initial symptom of normocalcemic primary hyperparathyroidism is extremely rare.Case presentation: A 69-year-old female patient was admitted to the hospital with a mass in the right thigh. A mass lesion of the right distal femur with bone and soft tissue infiltration was observed in the lower extremity mag...

ea0049ep337 | Clinical case reports - Thyroid/Others | ECE2017

Symptomatic bisphosphonate-induced hypocalcaemia after severe idiopathic hypercalcaemia

Ferreira Joana Lima , Tavares Teresa , Moco Rui , Melo Pedro

Introduction: Bisphosphonates, generally considered as safe drugs, are potent inhibitors of bone calcium outflow used to treat osteoporosis and hypercalcemia associated with malignancy. Bisphosphonate-induced hypocalcaemia is an increasingly reported complication, but it has not yet been a subject of comprehensive research.Case report: A 65-year-old woman had a history of Crohn’s disease and ankylosing spondylitis medicated with prednisolone and eta...

ea0049ep338 | Clinical case reports - Thyroid/Others | ECE2017

Transient hyperglycemia during the course of primary hypoparathyroidism: Case study

Urbanczuk Magdalena , Lewicki Marcin , Zwolak Agnieszka , Urbanczuk Marcin , Swirska Joanna , Lenart-Lipinska Monika , Tarach Jerzy S

Introduction: Calcium ions (Ca2+) play an essential role in process of correct β-cell insulin secretion. Hypocalcemia impairs insulin secretion leading to glucose metabolism disorders and insulin resistance.Case study: 62 -year old female patient with 18 years history of type 2 diabetes, treated with insulin, suspected of hypoparathyroidism, was admitted to the Department and Clinic of Endocrinology, Medical University of Lublin because o...

ea0049ep339 | Clinical case reports - Thyroid/Others | ECE2017

Hyperparathyroidism jaw tumour syndrome (HPT-JT)

Ahmed KS , Sherlock M , Stassen L , Timon C , Healy ML

Hyperparathyroidism jaw tumour syndrome (HPT-JT) is an autosomal dominant disease with variable penetrance. Onset is typically in late adolescence or early adulthood. Primary hyperparathyroidism is typically caused by a single parathyroid adenoma but parathyroid carcinoma occurs in 10–15%. Ossifying fibroma of the mandible or maxilla occurs in 30–40%, and may be locally aggressive. 15% of patients have renal manifestations which include polycystic kidney disease, Wil...

ea0049ep340 | Clinical case reports - Thyroid/Others | ECE2017

Fahr syndrome revealing a pseudohypoparathyroidism

Sakka Imen , Oueslati Ibtissem , Yazidi Meriem , Chihaoui Malika , Chaker Fatma , Rjeb Ons , Slimane Hedia

Introduction: Fahr syndrome is a rare entity characterized by the presence of bilateral intracranial calcifications with predilection for the basal ganglia and dentate nuclei. It is commonly associated with endocrine disorders, particularly parathyroid and Vitamin D disturbances. Herein we report a case of pseudohypoparathyroidism revealed by Fahr syndrome.Observation: A 29-old-year male was referred to our department for symptomatic hypocalcemia. He sho...

ea0049ep341 | Clinical case reports - Thyroid/Others | ECE2017

Parathyroid cyst: the forgotten diagnosis of a neck mass

Miranda Esperanza , Tome Mariana , Bautista Carmen , Gonzalez Daniel

Introduction: The differential diagnosis of cystic cervical masses includes thyroid cyst, thymic cyst, thyroglossal duct cyst, branchial cleft cyst, bronchogenic cyst, lymphangioma and parathyroid cyst (PC). PC is one of the less common causes of the cervical masses.Methods: We report the case of a 37-year-old man admitted to the hospital with a neck mass of 48 mm.Results: Our patient presented with neck pain and an hipoechogenic n...

ea0049ep342 | Clinical case reports - Thyroid/Others | ECE2017

“Pseudo or not”: differential diagnosis of hyperparathyroidism with severe electrolyte imbalance in transgender patient: a challenging case report

Ruza Ieva , Kundzina Linda

Introduction: Differential diagnosis between secondary hyperparathyroidism (SHPTH) and possible pseudohypoparathyroidism can be challenging in case of insufficient diagnostic tools and co-existing medical conditions. We report a diagnostic road to final diagnosis.Case report: A 48-years old white male-to-female transgender patient was admitted to our clinic for evaluation due to mental deterioration, general fatigue, slowly progressing bilateral upper ar...