Endocrine Abstracts

Introduction: Childhood obesity has become an important health problem nowadays. Intracranial lesions (IC) can affect the hypothalamic - hypophyseal axis depending on the localization of the lesion and lead to hypophyseal hormone deficiencies, especially growth hormone. Although IC lesions are important in the etiology of obesity, There’s limited data in the literature about this subject. Aim of this study is to evaluate the incidence of IC lesions and their role in clini...

Introduction: Congenital hyperinsulinism (CHI) is a heterogenous disease caused by insulin secretion regulatory defects, being ABCC8/KCNJ11 the most commonly affected genes. It can present as focal or diffuse pancreatic disease, which is mainly determined by the genotype. Diazoxide is the first-line medication in diffuse cases, however many do not respond satisfactory. Second-line options include somatostatin analogues and surgery, which is curative in case of focal CHI.<p...

Background: Recent data have been showed that free radicals are involved in either bone resorption and atherosclerosis development in adults. In paediatric population the important risk factor for the early atherosclerosis development is obesity, which can be also associated with the disturb bone turnover.Objective and hypotheses: The aim of the study was to evaluate the interrelationship between oxidative stress and bone turnover markers in obese childr...