Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

ea0049ep727 | Steroid metabolism + action | ECE2017

In vivo porcine and in vitro HepG2 models with 11β-HSD1 overproduction

Kang Hee Young , Lee Jae Hwan , An Jin Yong , Tran Dinh Nam , Jeung Eui-Bae

Introduction: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been associated with several human metabolic disorders and is converted from inactive 11-keto form to glucocorticoid (GC or cortisol). GC overproduction or hypercortisolism is a major diagnostic factor of Cushing syndrome and Anorexia. GCs regulate carbohydrate, fat, and protein metabolism.Materials and methods: Previously we established porcine fibroblasts overexpressing 11&#...

ea0049ep728 | Steroid metabolism + action | ECE2017

Hepatic and adipose tissue insulin resistance as a consequence of intermittent hypoxia are exacerbated by glucocorticoid receptor antagonism in man

Hazlehurst Jonathan , Charlton Catriona , Mantripp Diana , Hodson Leanne , Tomlinson Jeremy

Introduction: Obstructive sleep apnea (OSA) affects up to 20% of a Western population and is associated with non-alcoholic fatty liver disease and type 2 diabetes (T2D). OSA is characterized by intermittent episodes of hypoxia (IH) that occur during sleep. It is not yet known if IH is directly linked to insulin resistance within key metabolic target tissues (adipose; liver and skeletal muscle) and what the potential underlying mechanism may be. It has been suggested that indiv...

ea0049ep729 | Steroid metabolism + action | ECE2017

Dexras1 regulates MSC-derived adipogenesis and osteogenesis

Seok Jo Woon , Kim Daeun , Lee Hye min , Yoon Bo kyung , Kim Hyo Jung , Kim Jae-woo

Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into various types of cells including chondrocytes, osteoblasts and adipocytes. Since these types of cells are simultaneously derived from the same precursor cell, adipogenesis and osteoblastogenesis are thought to be counter-related. It is well-known that chronic treatment of steroid can induce Cushing’s syndrome which has phenotypes like visceral adiposity and osteoporosis. Cell fate of d...

ea0049ep730 | Steroid metabolism + action | ECE2017

Gender specific metabolic phenotype in the 5β-reductase knockout mouse

Gathercole Laura , Klusonova Petra , Nikolaou Nikolaos , Hazlehurst Jonathan , Moolla Ahmad , Dempster Niall , Penning Trevor , Cox Roger , Odermatt Alex , Tomlinson Jeremy

Steroid hormones and bile acids are potent regulators of metabolism. The enzyme 5β-reductase (AKR1D1) has a crucial role in bile acid synthesis and also generates 5β-reduced dihydrosteroid metabolites, regulating intra-cellular steroid availability though the clearance of cortisol, testosterone, androstenedione, and progesterone. As AKR1D1 sits at the interface of bile acid synthesis and steroid metabolism, we have hypothesised that it plays a key role in metabolic h...