Endocrine Abstracts

Sex hormone-binding globulin (SHBG) carries sex steroids in blood regulating their bioavailability. Red wine consumption increases plasma SHBG levels, and we have discovered that resveratrol, a polyphenol enriched in red wine, acts specifically through the human constitutive androstane receptor (CAR), a drug/xenobiotic detoxification gene regulator, to increase hepatic SHBG production. Chromatin immunoprecipitation and luciferase reporter gene assays show that human CAR binds ...

The anti-fibrotic, vasodilatory, and angiogenic therapeutic properties of relaxin peptide have been shown in several animal models of human diseases and in clinical trials. Using high-throughput screening of small molecule library, structure-activity relationship (SAR) studies, ligand-receptor interaction modeling, site-specific mutagenesis, and transgenic animal studies we discovered the first series of small molecule agonists of relaxin GPCR, RXFP1. The lead compound ML290 i...

Objective: Analyse the features of first patients treated with PCSK9 inhibitors in a specific Familial dyslipidemia Unit and the effects on lipid profile in first months of treatment.Material and methods: Data from patients with heterozygous familial hypercholesterolemia treated with PCSK9 inhibitors were reviewed. Clinical data, physical examination and analytical data were collected at baseline, one month and 3 months.Results: Da...

Objective: Analyse possible effects on physical examination, blood count, liver and kidney function, and steroidogenic hormones synthesis. Know the satisfaction of patients with the first injectable treatment for hypercholesterolemia approved in our country.Material and methods: Data were collected from patients with heterozygous familial hypercholesterolemia treated with PCSK9 inhibitors. Clinical, physical and analytical data were collected at baseline...

Objectives: The AMANDHA randomized study (PROBE design) showed that the addition of Manidipine 20 mg vs Amlodipine 10 mg for 2 years in 91 hypertensive type 2 diabetic patients with persistent microalbuminuria, uncontrolled with a renin-angiotensin system inhibitor (given full-dose for at least the 6 previous months) was more effective in reducing albuminuria in spite of similar blood pressure control. Patients with significant renal impairment (PlCr >1.4 mg/dl in women an...

Calcineurin inhibitors (CNI, cyclosporine A: CsA and tacrolimus: Tac) cause posttransplant diabetes mellitus, hypercholesterolemia and hypertension. Post-transplant weight gain can be related to the type of CNIs. Distribution of obesity is one of the major predictors of cardiovascular diseases. Several indices assessed upper body obesity such as waist circumference (WC) and waist to hip ratio (WHR) are more accurate than whole body obesity (body mass index: BMI). This study ai...

After a successful kidney transplant, the nutrition of patients is improved and they gain weight. Increased appetite due to medication, age of transplant, gender, race, pre-transplant obesity story and dialysis type increase the obesity frequency. We aimed to evaluate the effect of gender on nutrition and exercise habits on transplant recipients.Methods: Stable patients were divided into two groups according to gender: 29 males and 33 females. Their nutr...

The aim of the study was to defined the level of rehabilitation after the stroke depending on the type of hyperglycemia.Materials and methods: The retrospective analysis of 122 (54 female and 68 men) cases of ischemic stroke (IS) has been done. The diagnosis of IS was confirmed by computer tomography. According to the level of hyperglycemia at the debut of IS the patients were divided into three groups. Group 1 (60 patients) – with normoglycemia, gr...

Vitamin D plays a key role in the control of cardiovascular diseases (CVDs), acting as negative regulator of renin-angiotensin-aldosterone-system (RAAS), whereas calcium directly affects central blood pressure (BP) control center, nucleus tractus solitarus. We investigated associations between plasma concentrations of vitamin D and calcium and BP in 100 hypertensive CVDs patients and 100 normotensive subjects of 21–60 years. Vitamin D concentrations were measured using EC...