Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

ea0049ep784 | Endocrine tumours and neoplasia | ECE2017

Multidisciplinary committee on endocrine tumors: an analysis of 6-year experience

Diez Juan J , Iglesias Pedro , Alonso-Gordoa Teresa , Grande Enrique , Gajate Pablo

Aim: Multidisciplinary approach is mandatory in the management of endocrine tumors. Herein, we summarize the healthcare activity performed during the last 6 years at the multidisciplinary committee for endocrine tumors of a tertiary and University Hospital.Methods: A search of clinical-care activity of the endocrine tumors committee of our hospital from 2011 to 2016 was performed. Clinical and demographic data of all patients were recorded. The committee...

ea0049ep785 | Endocrine tumours and neoplasia | ECE2017

ER status heterogeneity in breast cancer: role in response to endocrine treatment

Gagliano Teresa , Ditsiou Angeliki , Grothey Arnhild , Giamas Georgios

Tumor heterogeneity affects diagnosis, prognosis and response to therapy. Heterogeneity is found in both normal and neoplastic human mammary gland. For example, luminal estrogen receptor (ER)-negative cells can give rise to various phenotypes, including ER-negative and ER-positive mammary tumors, suggesting that the cell-of-origin does not necessarily reflect the tumor type. Regarding ER status, heterogeneity can challenge endocrine therapies; elimination of responsive clones ...

ea0049ep786 | Endocrine tumours and neoplasia | ECE2017

Potential role of vitamin D in restoring sensitivity to mTOR inhibitors in hepatocellular carcinoma (HCC): 1,25(OH)vitamin D (VitD) reverts everolimus (EVE) resistance in a hcc cell line

Pivonello Claudia , Provvisiero Donatella Paola , Negri Mariarosaria , Gennaro Gilda Di , de Angelis Cristina , Simeoli Chiara , Galdiero Giacomo , Martino Maria Cristina De , Colao Annamaria , Pivonello Rosario

HCC is a difficult-to-treat- cancer with poor prognosis. Despite EVOLVE-1 trial demonstrated that EVE did not improve overall survival in molecularly and clinically unselected patients with advanced sorafenib resistant HCC, in selected patients, the established antitumor effect of EVE could make this drug a potential adjuvant therapy. Unfortunately, the acquired EVE resistance due to the tumour adaptation to chronic drug use is a current challenge. VitD has been deemed as pote...

ea0049ep787 | Endocrine tumours and neoplasia | ECE2017

Comparisson of subtraction and two-phase parathyroid scintigraphy conserning histological type of hyperfunctioning parathyroid tissue

Dugonjic Sanja , Ajdinovic Boris , Cerovic Snezana , Hajdukovic Zoran

The aim of this study was comparison of sensitivity of subtraction parathyroid scintigraphy (SBPS), vs. two-phase parathyroid scintigraphy (2FPS), related to histological type of hyperfunctioning parathyroid tissue.Materials and methods: Fifty patients, thirty with primary hyperparathyroidism and twenty on dialysis and secondary hyperparathyroidism underwent parathyroid scintigraphy (PS) before surgery. Static scintigrams of neck and chest were performed...

ea0049ep788 | Endocrine tumours and neoplasia | ECE2017

Endocrine health problems detected in 764 patients evaluated in a late effects clinic

Pereira Conceicao , Pereira Joana , Dias Daniela , Donato Sara , Salgado Dauarte

Context: Many pediatric cancer survivors have endocrine conditions. After alkylating agents, steroids, methotrexate and radiation, several endocrine dysfunctions may appear. Surveillance for late effects is recommended by worldwide guidelines.Objective: The objective of the study was to describe the endocrine outcomes of 764 patients followed during a 20 years period in our out-patient clinic.Design: The design was a retrospective ...

ea0049ep789 | Endocrine tumours and neoplasia | ECE2017

Magmas modulates chemoresistance in endocrine-related cancers

Riva Eleonora , Tagliati Federico , Gagliano Teresa , Trapella Claudio , Missiroli Sonia , Pinton Paolo , Bertolucci Cristiano , degli Uberti Ettore , Chiara Zatelli Maria

: Magmas, a gene encoding for the mitochondrial import inner membrane translocase subunit, Tim16, protects different cell lines from the antitumoral effects of several pro-apoptotic stimuli (i.e. chemicals and chemotherapeutic agents). The synthetic Compound 5 is capable of sensitizing chemoresistant tumor cells overexpressing Magmas to proapoptotic stimuli, indicating that this molecule may be useful to overcome tumor chemoresistance. The aim of our study was to evaluate whet...

ea0049ep790 | Endocrine tumours and neoplasia | ECE2017

Altered expression of the components of the splicing machinery is associated to increased malignancy and expression of aberrant splicing variants in prostate cancer

Jimenez-Vacas Juan M , Gahete Manuel D , Pedraza-Arevalo Sergio , del Rio-Moreno Mercedes , Hormaechea-Agulla Daniel , Gomez-Gomez Enrique , Carrasco-Valiente Julia , del Mar Moreno Maria , Jose Requena-Tapia Maria , Castano Justo P , Luque Raul M

: Prostate cancer (PCa) is the most common cancer among men in developed countries. Unfortunately, the heterogeneity of this malignancy hinders the finding of new biomarkers and therapeutic tools. A potential factor contributing to PCa is alternative splicing, which can generate the appearance of oncogenic variants involved in PCa aggressiveness. Thus, we hypothesized that the alteration of the splicing machinery (spliceosome components and splicing factors (SFs)) could be ass...

ea0049ep791 | Endocrine tumours and neoplasia | ECE2017

Polyglandular autoimmune syndrome type III b

Vaz de Castro Raquel , Maria Aragues Jose , Ferreira Florbela , Gomes Vania , Wessling Ana , Tavares Lurdes , Ribeiro Joana , Alves Irina , Camilo Fernandes Afonso , Joao Bugalho Maria

: We report the case of a 57-year-old female diagnosed with Grave’s disease fifteen years before (TSH <0.001 U/ml; FT4 2.3 ng/dl; FT3 7.2 ng/dl, TSAbs 17 U/l). Persistency of hyperthyroidism despite antithyroid therapy led to total thyroidectomy three years after the diagnosis. Thereafter, thyroid function remained normal under hormonal replacement with levothyroxine. The patient had also been diagnosed with Pernicious Anemia at 47 years of age after investigation for...

ea0049ep792 | Endocrine tumours and neoplasia | ECE2017

Chronic stress and somatotroph axis in breast cancer more than a simple association

Crumpei Iulia , Armasu Ioana , Danciu Mihai , Tofan Mariana , Volovat Constantin , Belceanu Alina , Crumpei Felicia , Adomnicai Valentina , Vulpoi Carmen

Introduction: Epidemiological and clinical studies have proven direct correlations between chronic stress, inflammation and cancer progression. The inflammatory environment preexisting the malignant change and elevated IGF-1 levels are associated with higher cancer risk, especially through GH effects on cell proliferation and inhibition of apoptosis.Aim: To evaluate the relationship between biological and hormonal stress markers, growth factors and breas...