Endocrine Abstracts

Abstract: Idiopathic intracranial hypertension (IIH) is a devastating neurological condition, with elevated intracranial pressure of unknown aetiology. IIH is largely a disease of obese females of reproductive age. The clinical phenotype of IIH overlaps with polycystic ovary syndrome (PCOS), with prevalent obesity, hyperandrogenism and anovulation. In this study, we aimed to delineate the androgen excess phenotype of IIH women compared to those with PCOS and simple obesity. Wo...

Objective: To study epileptic seizures in patients with large and giant prolactinomas.Patients and methods: The study group included 45 patients with large prolactinoma (more 36 mm in diameter) and 23 patients with giant prolactinoma (more than 60 mm in diameter). 55 men and 13 women aged 16–67 years (mean 39). Patients were followed by hormone measurements, magnetic resonance imaging (MRI), electroencephalogram (EEG) and endocrinological, psychopat...

Introduction: A well known side effect of glucocorticoid treatment is abdominally centred weight gain due to increased sensation of hunger but the underlying mechanism is still only incompletely clarified. To elucidate whether the brain reward system is involved in this regulation we studied here the effects of an acute prednisolone infusion on brain centres responding to food stimulation by fMRI in healthy males and correlated these findings to the 24 h food intake of the sub...