Endocrine Abstracts

Pluripotent stem cells (PSC), both embryonic and induced (iPSC), are the most promising cell sources for replacement therapies. In particular for a disease like type 1 diabetes (T1D), caused by the loss of a single specific cell type that does not need to be transplanted back in its originating site to perform its function, a stem cell-based cell replacement therapy seems to be the ideal cure. At present, however, a successful strategy for the use of PSC in patients with diabe...

Abstract unavailable....

The recent discovery that genetically-modified α-cells can regenerate and convert into β-like cells in vivo holds great promise for diabetes research. However, to eventually translate these findings to human, it is crucial to discover compounds with similar activities. Herein, we report the identification of GABA as an inducer of α-to-β-like cell conversion in vivo. This conversion induces α-cell replacement mechanisms through the mob...