Endocrine Abstracts

Prostate stem cells have been proposed to participate in prostate cancer initiation. Furthermore, based on their androgen-independence, they are suspected to trigger prostate cancer recurrence when the tumor is no longer responsive to anti-androgens. Therefore better understanding the regulation of this particular cell pool may have important therapeutic relevance. In the human prostate, expression of prolactin (PRL) and activation of its major downstream signaling effector St...

Acromegaly is associated with increased soft tissue neoplasms, while GH deficient patients are protected from cancer development. Both environmental and age-related signals lead to cellular senescence and cell cycle dysregulation. We have shown that DNA damage-induced cellular senescence increases GH by inducing p53. GH, in turn, suppresses tumor suppressor proteins in both pituitary and nonpituitary cells.These observations led us to propose that intracellular epithelial GH i...

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