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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Oral Communications

Thyroid Disease 2

ea0049oc9.1 | Thyroid Disease 2 | ECE2017

Thyroid function and metabolic syndrome: results from the population-based LifeLines Cohort study

Wolffenbuttel Bruce , Wouters Hanneke , Slagter Sandra , van Waateringe Robert , van Vliet-Ostaptchouk Jana , Links Thera , van der Klauw Melanie

Background: The metabolic syndrome (MetS) is a combination of unfavourable health factors including abdominal obesity, dyslipidaemia, hypertension and impaired fasting glucose. Several small-scale studies have reported a relationship between thyroid function and some MetS components or suggested that serum FT3 levels within the normal range were independently associated with insulin resistance. We assessed how thyroid function relates to the prevalence of MetS in a large popul...

ea0049oc9.2 | Thyroid Disease 2 | ECE2017

Effect of restoration of euthyroidism in patients with hypothyroidism on cold induced thermogenesis

Maushart Claudia , Loeliger Rahel , Bathelt Cemile , Hutter Nina , Christ-Crain Mirjam , Betz Matthias

Background: Thyroid hormones have been shown to be necessary for proper function of brown adipose tissue (BAT) and cold induced thermogenesis (CIT) in rodent models. In humans hyperthyroidism has been demonstrated to activate BAT and increase thermogenesis. However, the data on CIT in humans in the hypothyroid vs. the euthyroid state are limited and conflicting.Methods: This was a prospective observational study. We recruited 40 patients presenting to a ...

ea0049oc9.3 | Thyroid Disease 2 | ECE2017

How much of the genetic predisposition to Hashimoto’s thyroiditis can be explained by genes commonly associated with the disease?

Skalniak Anna , Jabrocka-Hybel Agata , Piętkowski Jakub , Turek-Jabrocka Renata , Pach Dorota , Ludwig-Gałęzowska Agnieszka , Machlowska Julita , Kapusta Przemysław , Wołkow Paweł , Hubalewska-Dydejczyk Alicja

Background: Hashimoto’s thyroiditis (HT) is a common autoimmune disorder of the thyroid (AITD) which affects about 1–2% of the European population. The disease often clusters in families, which is why many attempts have been undertaken to find the genetic background that would underly the predisposition to HT. In contrast to another AITD - Graves’ disease, results of genetic analyses have been ambiguous and have failed to find a major genetic locus that would be...

ea0049oc9.4 | Thyroid Disease 2 | ECE2017

Thyroid dysfunction during the use of PD-1/PD-L1 blockade predicts its therapeutic response in the patients with advanced non-small cell lung cancer

Kim Hye In , Kim Tae Hyuk , Jang Hye Won , Kim Young Nam , Kim Hosu , Park So Young , Kim Sun Wook , Chung Jae Hoon

Background: PD-1/PD-L1 blockade is one of the promising drugs in the treatment of advanced non-small cell lung cancer (NSCLC). and predicting drug effect is important due to unique pattern of response. Immune-related adverse event (IRAE) might be associated with favorable clinical outcome. Thyroiditis is the most common IRAE which can be easily detected with the measurement of thyroid hormone levels. However, the relationship between thyroid dysfunction during the use of PD-1/...

ea0049oc9.5 | Thyroid Disease 2 | ECE2017

Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the ‘Serena Study’ a randomized, double-blind, placebo-controlled trial

Dato Carla Di , Mantovani Giovanna , Moretti Costanzo , Greco Ermanno , Bonomi Marco , Faggiano Antongiulio , Di Sante Stefania , Giannetta Vincenzo , Petrone Luisa , Fumarola Angela , Colao Annamaria , Lenzi Andrea , Isidori Andrea M. , Giannetta Elisa

Autoimmune thyroiditis and related complications represent a growing concern during pregnancy. Selenium is frequently present in nutraceuticals recommended for thyroiditis and pregnancy, given its advocated role in immunity, fertility and thyroid function. However, most evidences come from non-controlled studies. Materials and MethodsWe designed a multicenter, randomized, double-blind, placebo-controlled trial (Serena Study: NCT01465867) to evaluate the ...