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Endocrine Abstracts

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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

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Diabetes & complications 1

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Developmental & Protein Endocrinology
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Diabetes & complications 2

ea0049gp71 | Diabetes & complications 1 | ECE2017

Carbohydrates metabolism and H. pylori: case-control study

Cornejo-Pareja Isabel Ma , Roca-Rodriguez M Mar , Coin-Araguez Leticia , Munoz-Garach Araceli , Molina-Vega Maria , Diaz-Perdigones Cristina , Hernandez-Garcia Carmen , Alcaide-Torres Juan , Clu-Fernandez Carlos , Vinuela-Gonzalez Laura , Mora-Navas Laura , Mancha-Doblas Isabel , Tinahones-Madueno Francisco J

Introduction: H. pylori infection has been related with extragastric diseases such as type 2 diabetes.Aim: to evaluate changes in carbohydrate metabolism induced by 75g oral glucose tolerance test (OGTT), before and after antibiotic eradication treatment in patients colonized by H. pylori compared to healthy controls.Materials and methods: A prospective case-control study. Biochemical parameters, carbohydrate profile, ghrelin and G...
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ea0049gp72 | Diabetes & complications 1 | ECE2017

Specific plasma amino acids alternations associated with metabolic syndrome

Siomkajło Marta , Rybka Jacek , Gamian Andrzej , Stankiewicz-Olczyk Joanna , Bolanowski Marek , Daroszewski Jacek

Objectives: Amino acids (AA) plasma profile is associated with cardiometabolic diseases (CMD), predicts diabetes mellitus type 2 (DM2) and cardiovascular diseases (CVD) many years in advance. Metabolic syndrome (MS) defines the area of metabolic disturbances that precede DM2 and CVD development. The primary objective of the study was to examine the association between BCAA (branched chain amino acids), AAA (aromatic amino acids) profile and MS’s phenotype and to evaluate ...
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ea0049gp73 | Diabetes & complications 1 | ECE2017

Permanent neonatal diabetes in a 24 year old Spanish patient

Sierra Milagros , Garcia Elena , Males David , Romero Juan Carlos , Silva Carlos , Allo Gonzalo , Martinez Guillermo

Introduction: Neonatal diabetes mellitus is a rare form of diabetes, diagnosed within the first six months of life. We report a case of a 24-year-old patient with permanent neonatal diabetes.Case Report: The patient had no relevant family history. Her mother had no gestational diabetes. Personal history included: Normal birth weight, polycystic ovarian syndrome and ovarian teratomas. She was diagnosed of diabetes at 3 months of age, starting immediately ...
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ea0049gp74 | Diabetes & complications 1 | ECE2017

Rescue study of trapped AVPR2 mutants with chemicals

Erdem Beril , Saglar Emel , Karaduman Tugce , Ozcan Merve , Sahin Dilara , Mergen Hatice

Diabetes insipidus (DI) is a disorder that characterized by producing large volume of urine for daily due to the problems at the arginine vasopressin (AVP-NPII), aquaporin 2 (AQP2) and arginine vasopressin receptor 2 (AVPR2) genes. These problems can be inherited or acquired. Among these genes, AVPR2 is a G protein coupled receptor and most of the inherited type of DI are caused by mutations in AVPR2 gene. Mutations can cause improper folding of the receptor protein and this s...
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ea0049gp75 | Diabetes & complications 1 | ECE2017

GLP-1 acutely regulates carbohydrate and lipid metabolic routes in the liver

Toba Laura , Diz-Chaves Yolanda , Fandino Juan , Ogando Hugo , Gonzalez-Matias Lucas , Mallo Federico

The Glucagon-like peptide-1 receptor is widely expressed in diverse tissues including the liver. GLP-1 contributes itself to the regulation of glucose homeostasis and has important effects in lipid metabolism even preventing liver steatosis induced by high fat diets.The aim of this study was to analyse the short-term effects of liraglutide on key enzymes of the hepatic energy metabolism.Thirty-six Sprague-Dawley young adult male ra...
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ea0049gp76 | Diabetes & complications 1 | ECE2017

Increased risk of diabetes and hyperglycaemia associated with treatment with statins, beta-blockers and diuretics: the PPP-Botnia study

Hakaste Liisa , Helkkula Teo , Isomaa Bo , Taskinen Marja-Riitta , Groop Leif , Tuomi Tiinamaija

Background: Statin medication is commonly used in prevention of cardiovascular diseases. Pooled evidence shows that statin therapy is associated with increased risk of incident diabetes, but studies vary in results and there is no consensus of the diabetogenic mechanism of statins. Beta blockers and diuretics are commonly used antihypertensive agents that also have been shown to increase the risk of incident diabetes. Our objective was to examine the effects of statins, beta b...
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ea0049gp77 | Diabetes & complications 1 | ECE2017

Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection

Clerici Mario , Al-Daghri Nasser , Pontremolli C , Cagliani R , Forni Diego , Alokail Majed , Al-Attas Omar , Sabico Shaun , Riva S , Sironi M

Introduction: The endoplasmic reticulum enzyme glucose-6-phosphatase catalyzes the common terminal reaction in the gluconeogenic and glycogenolytic pathways and plays a central role in glucose homeostasis. In most mammals, different G6PC subunits are encoded by three paralogous genes (G6PC, G6PC2, and G6PC3). Mutations in G6PC and G6PC3 are responsible for human Mendelian diseases, whereas variants in G6PC2 are associated with fasting glucose (FG) levels.<p class="abstext"...
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ea0049gp78 | Diabetes &amp; complications 1 | ECE2017

Contribution of genetic predisposition and lifestyle to gestational diabetes risk

Popova Polina , Tkachuk Alexandra , Bolotko Yana , Gerasimov Andrey , Klyushina Alexandra , Kostareva Anna , Grineva Elena

Aim: The aim of our study was to assess the contribution of genetic variation in some previously reported gestational diabetes mellitus (GDM) susceptibility loci and lifestyle parameters to GDM risk.Methods: We performed a case-control study of 278 GDM cases and 179 controls who had filled up special questionnaires concerning their lifestyle habits during the oral glucose tolerance test (OGTT) on the 24–32 week of gestation. The questionnaire consis...
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ea0049gp79 | Diabetes &amp; complications 1 | ECE2017

The rs2292239 polymorphism in the ERBB3 gene is associated with risk for type 1 diabetes mellitus

Crispim Daisy , Dieter Cristine , Lemos Natalia , Assmann Tais , Duarte Guilherme , Dorfman Luiza , Bauer Andrea

Background and Aim: Type 1 diabetes mellitus (T1DM) is an autoimmune disease resulting from the complex interaction among multiple genes, environmental factors and the immune system. Genome-wide association studies identified ERBB3 (Erb-b2 receptor tyrosine kinase 3) gene as a main susceptibility locus for T1DM. This gene encodes a member of the family of intracellular receptors of protein tyrosine kinases, which activates multiple signaling pathways including PI3K-Ak...
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ea0049gp80 | Diabetes &amp; complications 1 | ECE2017

Trace elements as an oxidative stress marker in women with gestational diabetes and their neonates

Boutzios Georgios , Koukoulioti Eleni , Papoutsis Ioannis , Athanaselis Sotirios , Tsourouflis Gerasimos , Zapanti Evangelia

Background and aims: Gestational diabetes (GD) is closely related to unbalanced zinc (Zn) and cooper (Cu) serum levels. The aim of this study was to investigate serum zinc and cooper levels in relation to the metabolic profile, and the impact on fetal development in a cohort of gestational diabetes GD(N) neonates and their mothers GD(M) compared to normal pregnancies.Material and Methods: Prospective controlled study in a tertiary Academic medical center...
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ea0049gp81 | Diabetes &amp; complications 1 | ECE2017

Abstract withdrawn....
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ea0049gp82 | Diabetes &amp; complications 1 | ECE2017

Reduced level of soluble TLR2 in type 2 diabetes despite increased TLR2 monocyte expression

Zaharieva Emanuela , Velikova Tsvetelina , Vikentieva Elena , Popova Dora , Tsakova Adelina , Kamenov Zdravko

Background: Chronic low-grade inflammation is a major factor in the pathogenesis of type 2 diabetes. One way for promoting inflammatory cytokines secretion is through activation of toll-like receptors (TLR). Their overexpression on monocytes has been demonstrated in insulin resistance and type 2 diabetes. Soluble forms of toll-like receptors (sTLR) are considered a regulatory mechanisms of their activation. Their role has been described in modulation of bacteria-induced infect...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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