Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Guided Posters

Thyroid 2

ea0049gp206 | Thyroid 2 | ECE2017

Early use of steroid-sparing agents in treatment of moderate-to-severely active thyroid eye disease

Sipkova Zuzana , David Joel , Turner Helen , Norris Jonathan

Introduction: The management of active thyroid eye disease (TED) remains controversial. High dose intravenous methylprednisolone (IVMP) is the current recommended first-line treatment based on EUGOGO guidance. Such therapy has the potential for serious adverse effects. We present the outcomes of an alternative approach in the management of moderate-to-severely active TED, using steroid-sparing agents (SSAs) in conjunction with IVMP. Methotrexate is used as the first-line SSA a...

ea0049gp207 | Thyroid 2 | ECE2017

Prediction of response to methimazole based on clinical symptoms in new onset graves’ patients, using neural networks

Choi Hoon Sung , Yoo Won Sang

Introduction: Anti-thyroidal drug (ATD) therapy is a treatment of choice for Graves’ disease because of its effectiveness and low rate of adverse effect. Response to ATD or remission rate varies among individuals, although there were few useful clues for prediction of treatment response. We applied neural network model to predict response to methimazole, based on clinical symptoms at initial clinical symptoms.Methods & Design: We reviewed 20 new...

ea0049gp208 | Thyroid 2 | ECE2017

Serum Interleukin-37 (IL-37) levels were increased and correlated with oxidative stress parameters in Hashimoto’s Thyroiditis (HT) patients

Ruggeri Rosaria Maddalena , Vicchio Teresa Manuela , Alibrandi Angela , Giovinazzo Salvatore , Certo Rosaria , Giuffrida Giuseppe , Trimarchi Francesco , Gangemi Sebastiano , Cristani Mariateresa

Background: IL-37, member of the IL-1 family, is a natural suppressor of immune and inflammatory responses. Increased serum IL-37 levels were observed in several autoimmune diseases, including Graves’ disease. No data on TH are available from the literature.Materials and methods: We enrolled 45 euthyroid HT patients (5 M e 40 F, mean age 38.5±12.6) and 50 age- and sex-matched healthy controls. None was on LT-4 therapy. Smokers, subjects with ki...

ea0049gp209 | Thyroid 2 | ECE2017

The increased immunohistochemical expression of IL-23 in Hashimoto’s thyroiditis but not in Graves’ disease patients

Zake Tatjana , Skuja Sandra , Kalere Ieva , Konrade Ilze , Groma Valerija

Introduction: Recently, Th17 cells and their cytokines were identified to play an important role in the pathogenesis of thyroid autoimmunity. IL-23, produced by antigen presenting cells, is required for survival and differentiation of Th17 cells, and is known to guide T cells toward the Th17 phenotype. Its serum levels are increased in several autoimmune diseases, including Hashimoto’s thyroiditis (HT), however, the expression level of IL-23 within thyroid tissue assessed...

ea0049gp210 | Thyroid 2 | ECE2017

Laser ablation of benign thyroid nodules without anesthesia: clinical tolerance, hazards and complications

Vidal-Rios Pablo , Jimenez Teresa , Rodriguez Antonio , Villas Laura , Vidal-Rios Sebastian

Laser ablation of thyroid nodules has been used for the last two decads (Pacella et al, 2000). Surprisingly, complications are less frequent in patients treated without anesthesia, probably because eventual pain is an useful alarm symptom, leading the operator to repositioning the fiber during the procedure (Pacella et al., 2015).Material and methods: A total of 32 patients were included, without using local anesthesia. Nodules were solid, 5–72 ml v...

ea0049gp211 | Thyroid 2 | ECE2017

Orbital ectopic thyroid mistaken for mestastases

Jagucianskaite Greta , Petrenaite Agne , Ziukaite Rasa , Visockiene Zydrune

Introduction: Ectopic benign thyroid tissue outside the normal migration path of the thyroid is an extremely rare condition that, to our knowledge, has never been described in the orbit.Clinical case: 75-year-old woman with nodular thyroid was referred to Vilnius University Hospital Santariskiu Klinikos for fine needle aspiration biopsy. Her complaints were palpitations, difficulty swallowing, diplopia, exophthalmos with medial and –superio...

ea0049gp212 | Thyroid 2 | ECE2017

Association of the Period3 clock gene polymorphism with autoimmune thyroid diseases

Helvaci Nafiye , Oguz Seda , Kabacam Serkan , Karabulut Erdem , Akbiyik Filiz , Alikasifoglu Mehmet , Gurlek Alper

Background: Circadian rhythmicity is generated by a set of genes including Period3. Changes in the expression of Period3 and other clock genes have been linked with regulation of the immune system. Period3 polymorphisms have been associated with circadian disruption and so immune system dysregulation and altered secretion of several cytokines, which can lead to inflammatory and autoimmune disorders.Aim: To investigate the influence of a polymorphism in P...

ea0049gp213 | Thyroid 2 | ECE2017

IgG4-related fibrous variant of Hashimoto thyroiditis in a non-Asian woman

do Vale Sonia , Filipa Martins Ana , Costa Cristiana , Batista Lucas , Mendes de Almeida Margarida

Introduction: First described in 2009, IgG4-related thyroid disease includes several subcategories: Riedel’s thyroiditis, fibrous variant of Hashimoto thyroiditis (FVHT), IgG4-related Hashimoto thyroiditis (HT) and Graves’ disease with elevated IgG4. It is rare, with most cases described in Japan and characterized by increased IgG4 plasma cells at immunostaining.Case Report: A 59-year-old Caucasian women, without known Asian ancestry, was obser...

ea0049gp214 | Thyroid 2 | ECE2017

Thyroid hormones deficiencies and poor outcome in chronic heart failure outpatients

Triggiani Vincenzo , Licchelli Brunella , Terlizzese P , Grande D , Rizzo C , Lattarulo MS , Leopizzi T , Gioia I , Angelo Giagulli Vito , Guastamacchia Edoardo , Iacoviello Massimo

Background: Hypothyroidism and low T3 syndrome frequently occur in HF patients.Aim of the study: To evaluate in a large sample of CHF patients the association between thyroid hormone deficiencies and poor outcome.Methods and results: From 2006 to 2015, we screened 712 consecutive CHF outpatients (551 males, 64±14 years, left ventricular ejection fraction (LVEF) 33±10%, NYHA class 2.3±0.6, NTproBNP 2153±4696 pg/m...

ea0049gp215 | Thyroid 2 | ECE2017

Hypothyroidism and heart failure outcome: a study with a long-term follow-up

Triggiani V , Licchelli B , Rizzo C , Grande D , Terlizzese P , Leopizzi T , Gioia I , Giagulli VA , Guastamacchia E , Iacoviello M

Background: Hypothyroidism (HT) has been demonstrated to be associated to heart failure (HF) progression.Aim of the study: To evaluate the impact of HT on the progression of HF during a long-term follow-up.Methods: From 2006 to 2015, we evaluated 675 consecutive CHF outpatients (523 males, 64±13 years) in stable clinical conditions (>1 month) and in conventional therapy. They underwent a clinical evaluation, 12-lead ECG, e...

ea0049gp216 | Thyroid 2 | ECE2017

The correction of TSH with thyroid replacement therapy is associated with a better outcome in chronic heart failure patients

Triggiani V , Licchelli B , Grande D , Rizzo C , Terlizzese P , Giagulli VA , Lattarulo M.S , Leopizzi T , Gioia I , Guastamacchia E , Iacoviello M

Background: It has been previously demonstrated that thyroid hormone deficiency is associated with a worse outcome in patients affected by chronic heart failure (CHF). However, few data are available about the effects of thyroid replacement therapy on the prognosis of patients.Aim of the study: The aim of the study was to evaluate the relationship among thyroid replacement therapy, correction of thyroid stimulating hormone (TSH) serum levels and outcome ...