Endocrine Abstracts

Introduction: Prolactinomas are the most common pituitary tumors. Macroadenomas are rarely seen. Dopamine agonists such bromocriptin and cabergoline are the preferred treatments for prolactinomas. Herein, we report a patient with macroadenoma whose adenoma has resolved rapidly with cabergoline treatment.

Case: A 49 year old male patient evaluated for weakness and headache. After detection of central hypothyroidism he was referred to our department. His prolactin level was more than 1925 ng/ml. His laboratory tests were concordant with panhypopituitarism. Replacement therapy was initiated. A macroadenom with a size of 28 mm was detected in pituiter MRI. Cabergolin treatment (3 mg/week) was initiated. The size of the adenoma was decreased to 16 mm in the 3rd month of the therapy. In the 6th month of the treatment the size of the adenoma regressed to 5 mm.

Conclusion: Prolactinomas are tumors with a good response to medical treatment. A rapid response was detected in our patient but there is data about cabergolin resistance. So, a close follow up is required in patients with prolactinomas.