Nitric Oxide (NO) has been considered a very important molecule in the biological system because of its interaction with other molecules for mediating various bio-pathways. Its interaction with vitamin D in particular studied well in animal models, cell lines and patients with various diseases. However, the relationship between NO and vitamin D has never been studied in healthy adolescents. We aimed to determine the association of NO with vitamin D and other serological factors in healthy Saudi adolescents. We recruited 740 individuals (245 boys and 495 girls) from Riyadh, Saudi Arabia. Socioeconomic status, food habits, BMI and data regarding major medical complications were recoded. Blood samples were performed for estimation of vitamin D, traces of NO and other possible serological parameters. Data revealed that NO has inverse correlation with vitamin D but showed significant and positive association with serum triglycerides and systolic blood pressure. Here, it is suggested that some unknown limiting factors may restrict the relationship of NO and vitamin D in healthy individuals. Therefore, the factors which limit the NO association with vitamin D and other molecules should be investigated in vitro and in vivo.
20 - 23 May 2017
European Society of Endocrinology