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Endocrine Abstracts (2017) 49 EP35 | DOI: 10.1530/endoabs.49.EP35

ECE2017 Eposter Presentations: Adrenal and Neuroendocrine Tumours Adrenal cortex (to include Cushing's) (86 abstracts)

Treatment of adrenal insufficiency with hydrocortisone dual-release formulation: glycometabolic profile and health-related quality of life

Laura Maria Mongioì , Rosita Angela Condorelli , Laura Cimino , Sandro La Vignera & Aldo Eugenio Calogero


Unit of Andrology and Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Catania, Sicily, Italy.


Introduction: Treatment of adrenal insufficiency (AI) in the last years has been object of important changes due to the development of a dual-release preparation of hydrocortisone (Plenadren®). Hydrocortisone dual-release therapy contemplates a once-daily tablet that allows more closely mimicking the physiological circadian rhythm cortisol, thus avoiding overexposure.

Objective: The aim of the study was to value effects of Plenadren administration on the 24-h urinary free cortisol (UFC), the glycometabolic profile and health-related quality of life of patients with AI.

Methods and materials: We enrolled seven adults with secondary AI caused by panhypopituitarism (55.9±3.6 years) and seven adults with primary AI (36±6.2 years). We evaluated BMI, UFC levels, the glycometabolic profile and health-related quality of life (estimated by AddiQol questionnaire) before and 3, 6, 9 and 12 months after Plenadren administration. One patient dropped out the study for personal reasons.

Results: All patients, except one, reported a significant improvement of the quality of life after 3 months of treatment, whereas after 1 year everyone reported individual wellness. After 12 months of treatment, all parameters evaluated improved, though not in statistically significantly manner. The parameters for which there was evidence of a greater improvement were total cholesterol, low-density cholesterol and glycosylated hemoglobin levels.

Conclusions: The once-daily oral hydrocortisone dual-release therapy is a valid option for the treatment of patients with AI. It allows a good glycometabolic balance in the absence of side effects and improving compliance.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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