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Endocrine Abstracts (2017) 49 EP743 | DOI: 10.1530/endoabs.49.EP743

ECE2017 Eposter Presentations: Environment, Society and Governance Endocrine Disruptors (8 abstracts)

The protective role of Zingiber officinale extract against methyl thiophanate induced toxicity in male rats

Rachid Mosbah 1, , Malika Bahri 1 , Said Azzoug 3 , Zouhir Djerrou 4 & Alberto Mantovani 5


1Department of Biology, University of Boumerdes, Boumerdes, Algeria; 2Laboratory of Eco-biology, ENS Kouba, Algiers, Algeria; 3Hospital of Lamine Debaghine B.E.O, Algiers, Algeria; 4University of Skikda, Skikda, Algeria; 5Istituto Superiore di Sanità, Rome, Italy.


In this study, we attempted to assess the toxicity of Methyl Thiophanate (MT) on the biochemical and reproductive parameters in male Wistar rats as well as the possible protective role of Zingiber officinale (Ginger, Ging) extract against MT-induced toxicity. Hence, forty adult Wistar rats were allocated into four groups of 10 rats for each; the first group served as control, groups 2, 3 and 4 were treated orally (5/week) for 8 weeks by MT (150 mg/kg bw), Ging (100 mg/kg bw) and MT plus Ging respectively. At the end of experiment, blood samples were collected under anesthesia for measuring the biochemical parameters and testosterone level, while, the reproductive organs were excised and used for semen quality analysis and histopathological examinations. Results indicated that MT exposure increases the level of blood glucose, cholesterol, triglycerides, urea, uric acid, AST, ALT and total protein, whereas, no clear impact on testosterone level was noted compared to the control. Semen analysis showed a decrease in spermatids number, sperm count, motility and viability. Moreover, a marked histopathological damage in testis and epididymis was detected which reflect a poor semen quality. Ginger extract co-treatment with MT alleviates and/or repairs all adverse toxic effects caused by MT on the reproductive, biochemical and hispathological parameters. This amazing preventive role may be related to its potential antioxidant properties. In conclusion, ginger extract supplementation plays crucial protective role against MT-induced toxicity in male rats.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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