Endocrine Abstracts (2017) 49 EP982 | DOI: 10.1530/endoabs.49.EP982

The triglyceride (TG)/HDL Cholesterol (TG/HDL-C) ratio as marker of adipose tissue dysfunction at patients with acromegaly

Oksana Khyzhnyak, Miroslava Mykytyk & Iurii Karachentsev

Institute of Endocrine Pathology Problems, Kharkiv, Ukraine.

Background and aims: The ratio of TG/ HDL-C can identify cardiometabolic risk and cardiovascular disease. The visceral adiposity index (VAI) is a sex-specific index, in which measurements of body mass index and waist circumference are combined with TG and HDL-C concentrations. T? study association between VAI and TG/HDL-C and the value of TG/HDL-C ratio as a marker of disfunction of visceral adiposity tissue at patients with acromegaly.

Subjects and methods: Eighty-eight patients (30 men and 58 women; aged 17–75 years) with acromegaly were under investigation. Disease activity was evaluated according to the Consensus Conference criteria (2000). Blood samples for GH, IGF-1, TG, HDL-C and total cholesterol were taken in fasting state. VAI score and normal values used by M. C. Amato et al., 2011. It was considered the normal VAI in an age-dependent group to 30 years <2.52, from 31 to 42 years – <2.23, from 43 to 52 years – <1.92, from 53 to 66 years – <1.93 and more than 67 years – <2.00 Taking into account a value VAI, all patients were divided on two groups: with normal VAI (55.7%) (group 1) and high VAI (44.3%) (group 2). The 10-years-old general cardiovasculary risk (CVD) was determined by a calculator «General CVD Risk Prediction».

Results: At nonlinear correlation, TG/HDL-C ratio was highly correlated with VAI in both men (rs=0.96, P=0.00001) and women (rs=0.97, P=0.00001), that TG/HDL-C can serve as more adequate criterion of estimation of disfunction of visceral adiposity tissue at patients with acromegaly. This supposition confirms exposed by us for patients in a general group positive correlation TG/HDL-C with the level of GH (rs=0.38, P=0.0001). Before TG/HDL-C it was suggested to use for identification of cardiometabolic risk in general population (M. R. Salazar et al., 2014). In a group with high VAI 10-years-old CVD risk and MS risk in 1.6 and 1.4 times, according higher, than in a group with normal VAI (OR 1.56, OR 1.42).

Conclusion: By the equivalent of VAI for the estimation of expressed of disfunction of visceral adiposity tissue at patients with acromegaly can serve also TG/HDL-C ratio.

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