Endocrine Abstracts (2017) 49 OC6.4 | DOI: 10.1530/endoabs.49.OC6.4

Copeptin and its association to cardiovascular dysfunction in type 2 diabetes

Simona Ioana Chisalita1, Lee Ti Chong2, Fredrik Nyström1, Carl Johan Östgren3 & Toste Länne4


1Department of Endocrinology and Department of Medicine and Health Sciences, Linköping University, Linköping, Sweden; 2Department of Emergency and Department of Medicine and Health Sciences, Linköping University, Linköping, Sweden; 3Department of Medical and Health Sciences (IMH)/Division of Community, Linköping, Sweden; 4Department of Thoracic and Vascular Surgery, and Department of Medicine and Health Sciences, Linköping University, Linköping, Sweden.


Background: We aim to test whether plasma copeptin (copeptin), the C-terminal fragment of vasopressin, has predictive value of cardiovascular events in patients with type 2 diabetes without previous cardiovascular disease who were treated in primary care.

Methods: We measured copeptin in 697 patients who participated in the epidemiological study CARDIPP (Cardiovascular Risk Factors in Patients with Diabetes – a Prospective Study in Primary Care; ClinicalTrials.gov identifier NCT01049737) and who did not have previously known myocardial infarction or stroke. The outcome variable was a composite endpoint consisting of cardiovascular mortality, hospitalization for myocardial infarction and hospitalization for stroke.

Results: During a median follow-up time of almost 7 years, the unadjusted HR per each increment of Copeptin by 1 pmol/l was 3.5 (95% CI 1.7–7.1, P<0.001) for the primary endpoint. Following adjustments for age, sex, HbA1c, arterial stiffness (PWW) as well as atherosclerosis plaque the adjusted hazard ratio was 2.4 (95% CI 1.1–5.2, P=0.03).

Conclusions: In primary preventive patients with type 2 diabetes treated in primary care, copeptin predicted a composite outcome of incident cardiovascular events independently of age, sex, HbA1c, arterial stiffness as well as atherosclerosis plaque.

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