ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2017) 49 S28.3 | DOI: 10.1530/endoabs.49.S28.3

Kisspeptin and neurokinin B - novel reproductive hormones with therapeutic potential

Waljit Dhillo


UK.


Kisspeptin and neurokinin B are 2 novel key hypothalamic hormones which are vital in normal reproductive function. Inactivating mutations for the gene or the receptor for either of these peptides will cause a failure of puberty due to hypogonadtotrophic hypogondaism. In this talk I will present evidence to suggest that kisspeptin is important in sexual and emotional processing in humans (1). In addition I will present evidence which suggests that NK3R (the receptor for NKB in humans) is important as a mediator of menopausal flushing and this has potentially practice changing therapeutic potential (2).

References

1. Comninos AN, et al. Kisspeptin modulates sexual and emotional brain processing in humans. J Clin Invest. 2017 127 709–719. https://www.jci.org/articles/view/89519

2. Comninos AN, et al. Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet online on 3rd April 2017 http://dx.doi.org/10.1016/S0140-6736(17)30823-1

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