Kisspeptin and neurokinin B are 2 novel key hypothalamic hormones which are vital in normal reproductive function. Inactivating mutations for the gene or the receptor for either of these peptides will cause a failure of puberty due to hypogonadtotrophic hypogondaism. In this talk I will present evidence to suggest that kisspeptin is important in sexual and emotional processing in humans (1). In addition I will present evidence which suggests that NK3R (the receptor for NKB in humans) is important as a mediator of menopausal flushing and this has potentially practice changing therapeutic potential (2).
1. Comninos AN, et al. Kisspeptin modulates sexual and emotional brain processing in humans. J Clin Invest. 2017 127 709719. https://www.jci.org/articles/view/89519
2. Comninos AN, et al. Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet online on 3rd April 2017 http://dx.doi.org/10.1016/S0140-6736(17)30823-1
20 - 23 May 2017
European Society of Endocrinology