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Endocrine Abstracts (2017) 49 S8.2 | DOI: 10.1530/endoabs.49.S8.2

ECE2017 Symposia Predictors of therapeutic response in functioning pituitary tumours (3 abstracts)

MRI predictors of therapeutic response in GH-secreting pituitary tumours

Jean Francois Bonneville


Belgium.


The T2-weighted characteristics of GH-secreting pituitary adenomas have recently received particular attention from the research community. It now appears that somatotropinomas can be divided into groups with different behavior according to their T2-weighted signal. T2-hypointense adenomas are generally smaller, invade the cavernous sinus less frequently and are responsible for higher levels of GH-hypersecretion (Fig. 1). Treatment with somatostatin analogues, both before and after surgery, leads to different responses of T2-hypointense adenomas versus non-hypointense tumours. The T2-hypointense adenomas have higher GH and IGF1 decreases and more important tumour shrinkage rates (1). It is therefore interesting to have high quality T2-weighted MRI images at the diagnosis of acromegaly, as it allows to estimate disease evolution and to orient the management strategy.

Reference

1. Potorac, J et al. T2-weighted MRI signal predicts hormone and tumor responses to somatostatin analogs in acromegaly. Endocr Relat Cancer 23(11):871-881.

Figure 1 Hyperintense (a) and hypointense (b) GH-secreting adenomas on T2 W MRI.

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Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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