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Endocrine Abstracts (2017) 49 EP1167 | DOI: 10.1530/endoabs.49.EP1167

1Deparment of Internal Medicine, Selcuk University Faculty of Medicine, Konya, Turkey; 2Division of Endocrinology and Metabolism, Selcuk University Faculty of Medicine, Konya, Turkey; 3Department of Biochemistry, Selcuk University Faculty of Medicine, Konya, Turkey; 4Department of Obstetrics and Gynecology, Selcuk University Faculty of Medicine, Konya, Turkey; 5Department of Dermatology, Selcuk University Faculty of Medicine, Konya, Turkey.


Introduction: There is some evidence that a rise in the androgen hormone levels increases the risk for the development of a cardiovascular disease, obtained from the studies conducted on women with polycystic ovary and on men with androgenic alopecia. Inflammatory substances tend to increase in polycystic ovary syndrome and in androgenic alopecia. On this basis, we conducted a study that aimed to evaluate the early cardiovascular and metabolic effects in male patients with androgenic alopecia.

Methods: A total of 81 people, of whom 41 were patients with androgenic alopecia and 40 were healthy controls, were included in the study. Aged from 25 to 45, none of them had any cardiovascular risk factors, malignancy, any active infections and any liver or kidney diseases. Ambulatory blood pressure was measured for 24 h and sensitive CRP and galectin-3 were studied so as to assess the cardiovascular and metabolic risk.

Results: There were no differences between the patient and control groups in terms of ambulatory blood pressure of 24 h, sensitive CRP and galectin-3. A positive correlation was found in the patient group between sensitive CRP and waist and neck circumferences. While there was a positive correlation in the patient group between galektin-3 and HOMA-IR, waist and neck circumferences, a negative correlation was seen with free testosterone. Alopecia level correlated positively with daytime pulse wave velocity and night time reflection magnitude.

Conclusion: We did not find any difference in our study in terms of arterial stiffness and chronic inflammation in the early period when the control and androgenic alopecia groups were compared; however, a positive correlation between alopecia level and daytime pulse wave velocity and night time reflection magnitude may be considered as an early signal for atherosclerosis.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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