Endocrine Abstracts (2017) 49 EP1187 | DOI: 10.1530/endoabs.49.EP1187

The disorder of secretion of somatotropic hormone in women with obesity in the polycystic ovaries syndrome (PCOS) by comparison to patients with the non-functional pituitary adenomas (NFPA)

Saidganokhoja Ismailov & Maryam Abduvakhabova


Tashkent Paediatric Medical Institute, Tashkent, Uzbekistan.


Aim: To study the disorder of secretion of growth hormone for women with obesity in PCOS by comparison to patients with NFPA.

Materials and methods: Under our supervision in the department of neuroendocrinology of the Center of Endocrinology of PH Ministry of RUz ambulatory in a period from September 2015 for December, to 2016, 15 adult patients of fertil age were observed with obesity in PCOS and 15 – with NFPA. Middle age of patients to make 25.5 and 28.9 accordingly. The remoteness of disease hesitated in limits from 7 months to 9 years.

Results: It was set that in both groups there were neuroendocrine violations peculiar to each of pathologies. So, in a 1 group of patients with PCOS such violations, as obesity, met most often, strium, acanthosis, acne, hyperandrogenemiya. hyperpolymenorheya, and in the second is secondary amenorrheya, hyperprolactinemiya, pahhypopituitarism. In both groups there was anovulation, and also decline of secretion of STH, IGF- 1. In addition, in the group of patients with NFPA the most for certain mionectic basale levels of trope hormones of hypophysis were educed - STH, LH, FSH on a background hyperprolactinemiya and normal values of IGF- 1, while for patients with PCOS the decline of STH, LH, FSH, was marked on a background hyperandrogenemiya and declines of IGF- 1.

Conclusions: 1) It is set that in the group of patients with PCOS the most reliable decline of basale levels of IGF- 1 was educed, while the deficit of STH met rarer.

2) For patients with NFPA took place panhypopituiarism, namely combined deficiency of STH, LH, FSH, TSH, while the deficit of IGF- 1 met rarer.

3) The secretions of STH and IGF- 1 educed in our research of violation confirm these literatures that for patients with PCOS the decline of levels of STH and IGF- 1 takes place on a background of hyperinsulinemiya and hyperandrogenemiya, that requires further research.

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