Endocrine Abstracts (2017) 49 EP235 | DOI: 10.1530/endoabs.49.EP235

Bone histomorphometry and bone marrow adipocytes in premenopausal women with type 2 diabetes

Vicente Andrade1, Victoria Borba1, Domingos Chula1, Fellype Barreto2, Cesar Boguszewski1 & Carolina Moreira1,2


1Endocrine Division of Feral/University of Parana – SEMPR, Curitiba, Brazil; 2LABORATORY PRO, Histomorphometry sivision, Pro Renal Foundation, Curitiba, Brazil.


Few studies have evaluated bone histomorphometry in type 2 diabetic patients (DM2) and none has established if the disease control plays a role on bone morphology and bone marrow adipocytes. The aim of this study is to present preliminary data on bone microstructure, bone formation rate and bone marrow adipocytes in premenopausal women with DM2 with different levels of glucose control. Bone biopsy, followed by tetracycline labelling, was obtained for analysis of static and dynamic parameters of bone histomorphometry and volume of bone marrow adipocytes. To date, 12 bone biopsies and 6 histomorphometry analysis were performed in a group of women with mean age of 40.9±6.0 yrs, mean duration of DM2 of 6.8±2.6 years and median glycosylated haemoglobin of 8,1% (range 6.5–12.3). Initial results have shown a normal bone volume, reduced bone formation and an increase in adipocytes content in comparison to normal premenopausal women values at the literature. Our preliminary results suggest that bone morphology and bone marrow adipocytes content is altered in premenopausal women with DM2.

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