Adiponectin has been thought to exert important influences in energy homeostasis and insulin signalling pathway. Some obese individuals showed paradoxical hyperadiponectine-mia (HA), however, the effect of HA on bone metabolism has not been fully clarified.
This study aimed to evaluate bone strength and metabolic parameters according to the presence of HA and obesity in Korean adults. A total of 9,172 adults (59.4% women) aged 4070 years assessed in the Korean Genomic Rural Cohort Study from 2005 to 2008 were examined. HA was defined as the levels of higher than or equal to the upper tertile among metabolically healthy subjects with a bone mass index (BMI) less than 23 kg/m2.
Moreover, obesity was defined as a BMI of more than or equal to 25 kg/m2. The serum con-centrations of adiponecti-n were measured by radioimmunoassay. In addition, bone status was assessed using the calcaneal quantitative ultrasound method. Obese subjects and those who have HA accounted for 40.3% and 15.7%, respectively; about twenty percent of the non-obese and 9.5% of the obese had HA. Although most of metabolic parameters such as fasting glucose and lipid profiles were significantly better in the HA group compared with the non-HA group, bone stiffness index (BSI) in the former was lower in the latter. In both the non-obese and obese groups, individuals with HA had lower waist circumference and BSI. Moreover, obese subjects without HA showed the highest BSI levels among the group-s, which was especially prominent in women. Our results suggest that bone strength in obese individuals may be more negatively affected by high adiponectin levels. Further studies are necessary to confirm the effects of adiponectin on bone health in subjects with obesity.
20 - 23 May 2017
European Society of Endocrinology