Endocrine Abstracts

Introduction: According to modern studies, patients with hypercalcemia have an increased cardiovascular risk.

Objective: To study the prevalence of cardiovascular disease in patients with hypercalcemia.

Materials and methods: We studied 1207 people, average age 53.9±17.25 (892 women, 315 men) from 18 to 96 years. Examination: total calcium, total protein, creatinine, cholesterol and triglycerides, HbA1C, ambulatory blood pressure monitoring, ECG, an analysis of morbidity (hypertension, coronary heart disease, cardiovascular events).

Results: Hypercalcemia has been found in 31 people, mean age was 58.39±11.6 years. Arterial hypertension was detected in 677 cases (in patients with hypercalcemia – in 23 patients), coronary heart disease was detected in 599 cases (in patients with hypercalcemia – 21), acute myocardial infarction – in 52 cases (in patients with hypercalcemia – 1), acute cerebrovascular accident – in 39 cases (in patients with hypercalcemia – 1).

Significant differences in the prevalence of arterial hypertension (χ²=4.03, P=0.0447); in the prevalence of coronary heart disease (χ²=3.87, P=0.046) in patients with hypercalcemia were detected. In the same time the differences in the prevalence of acute myocardial infarction (χ²=0.09, P=0.8) and acute cerebrovascular accident (χ²=0, P=1) in patients with hypercalcemia were not revealed.

Conclusion: The results of the study show an increasing risk of arterial hypertension and coronary heart disease in patients with hypercalcaemia. In the same time the risk of acute cardiovascular events is not increased. The results may suggest the influence of hypercalcemia on the development of cardiovascular disease.