Endocrine Abstracts (2017) 49 EP344 | DOI: 10.1530/endoabs.49.EP344

Differential roles of carboxylated and uncarboxylated Osteocalcin in stage I breast cancer as a diagnostic biomarker

Anara Karaca1, Nese Ersoz Gulcelik1, Filiz Bakar2, Giray Akgul3, Zeynep Sahiner1 & Mehmet Ali Gulcelik3


1Ankara Teaching and Research Hospital, Endocrinology and Metabolism, Ankara, Turkey; 2Ankara University, School of Pharmacy, Biochemistry, Ankara, Turkey; 3Ankara Oncology Teaching and Research Hospital, General Surgery, Ankara, Turkey.


Objective: The finding of new biomarkers is needed to have an early diagnosis of breast cancer. In this study we evaluated serum levels of carboxylated osteocalcin (OC) and uncarboxylated osteocalcin(UcOC), CRP as a diagnostic biomarker for breast cancer.

Design and methods: Blood samples of 39 women with newly diagnosed breast cancer with stage I were obtained before surgery and 39 age and BMI matched health women were selected as controls.

Results: The mean age was 52±7 years (P=0.8). Circulating logOC was significantly lower in breast cancer patients compared to controls (2±1.1 mg/ml vs. 3±1.23 mg/ml, P<0.05), while logCRP levels were significantly higher in breast cancer patients than controls (0.8 vs. −0.6, P<0.05). Serum levels of logUcOC were not different between groups(6.39±0.4 mmol/l vs. 6.39±0.9 mmol/l, P=NS). OC had a positive correlation with ucOC (r=0.3, P=0.03). In contrast, CRP was not correlated with OC and ucOC (P=0.2, P=0.3, respectively).

Conclusion: We conclude that circulating OC has a potential use as a sensitive diagnostic biomarker for early detection of breast cancer.

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