Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2017) 49 EP357 | DOI: 10.1530/endoabs.49.EP357

ECE2017 Eposter Presentations: Diabetes, Obesity and Metabolism Cardiovascular Endocrinology and Lipid Metabolism (29 abstracts)

Metformin and changes in blood pressure and heart rate in lean patients with polycystic ovary syndrome (PCOS)- preliminary study

Marta Kialka 1 , Tomasz Milewicz 1 , Marek Klocek 2 & Rita Tomczyk 1


1Department of Gynecological Endocrinology, Jagiellonian University, Medical College, Cracow, Poland; 2Department of Cardiology and Hypertension, Jagiellonian University, Medical College, Cracow, Poland.


Introduction: The aim of our study was to assess the value of blood pressure and heart rate using the 24-h blood pressure monitoring (ABPM) before and after treatment with metformin to patients with polycystic ovary syndrome (PCOS) and normal lean.

Material and methods: 20 patients received metformin 1500 mg/day in three divided doses. ABPM was performed to each patient with PCOS twice: before and after 6 months of treatment with metformin.

Results: In patients with PCOS and normal lean after treatment with metformin we observed: statistically significant lower systolic blood pressure (120.2±22.33 mmHg vs 113.22±21.43 mm Hg, P=0.0248); lower systolic blood pressure of daily measurements (127.1±32.13 mmHg vs 116.1±22.08 mmHg, P=0.0062); reduction in average arterial pressure MAP daily measurements (95.52±22.76 mmHg vs 88.36±16.41 mmHg, P=0.048); oscillometric pressure reduction (96.27±27.93 mmHg vs 87.82±21.61, P=0.0004 mmHg); oscillometric pressure reduction of daily measurements (102.1±27.93 mmHg vs 91.85±21.61 mmHg, P=0.0032); oscillometric pressure reduction in the measurement of the night (88.81±24.85 mmHg vs 82.22±20.54 mmHg, P=0.0089). In women after treatment with metformin has also been observed higher average heart rate (65.82±13.48/min vs. 70.71±16.04/min; P <0.01). The calculations included 500 measurements.

Conclusion: Treatment with metformin in patients with PCOS and normal lean leads to lower blood pressure and increases the frequency of heart rate.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.