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Endocrine Abstracts (2017) 49 EP429 | DOI: 10.1530/endoabs.49.EP429

1Regional Training and Research Hospital, Erzurum, Turkey; 2Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey; 3Ataturk Training and Research Hospital, Ankara, Turkey.


Purpose: The purpose of this study was to evaluate the relation gestational diabetes mellitus (GDM) and the thiol/disulfide balance, used as a marker of oxidative stress, by measuring that exchange using a novel technique.

Material/Methods: Thirty one subjects diagnosed with GDM and 30 healthy pregnant women were included in the study. Thiol/disulfide homeostasis concentrations were measured by a newly developed method in this study. After native thiol, total thiol and disulfide levels were determined; measures such as disulfide/ native thiol, disulfide/total thiol, and native thiol/total thiol were calculated.

Results: Fasting blood glucose (FBG) levels (P<0.001), 50-g glucose load values (OGTT 50) (P<0.001), parity (0.002) and gravidity (P=0.005) were significantly higher and native thiol (P<0.001) and total thiol levels (P<0.001) were significantly lower in patients with GDM compared to control subjects. We found negative correlations between native and total thiols and FBG and OGTT 50. Parity and gravidity had a significantly negative correlation between the disulfide, the disulfide/native thiol ratio, the disulfide/total thiol ratio, had a positive correlation between the native thiol/total thiol ratio. Low native thiol and total thiol levels in patients with GDM were found to be independent of age, gestational weeks and bmi in multivariate regression analyse.

Conclusion: It can be concluded that oxidative stress is increased in patients with GDM, can play a pathophysiological role in the development of GDM and this increase is not associated age, gestational weeks and bmi. However, studies with larger sample sizes are needed in this area.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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