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Endocrine Abstracts (2017) 49 EP430 | DOI: 10.1530/endoabs.49.EP430

1St. Vincent’s University Hospital, Dublin, Ireland; 2University College Dublin School of Medicine, Dublin, Ireland.


Postprandial hypoglycaemia in patients with cystic fibrosis (PWCF) is frequently reported but poorly understood. The aim of this pilot study was to investigate the aetiology of postprandial hypoglycaemia in PWCF. Serum cortisol, insulin and C-Peptide were measured at the 2 hour timepoint of the annual glucose tolerance test in 32 PWCF not known to have CF-related diabetes. Hypoglycaemia was defined as glucose < 3.3 mmol/l. Patients were classified as Normal glucose tolerance (NGT; n=17), Post prandial hypoglycaemia (PPH; 6) and Abnormal glucose tolerance (AGT; 9–3 CF related diabetes, 4 impaired fasting glucose and 2 impaired glucose tolerance). There was a difference in insulin level at 2 hours between groups (P=0.007, Wilcoxon); subanalysis showed a difference between AGT (mean 48.9 mu/l) and PPH groups (16.6 mu/l)(P 0.003) and between AGT and NGT groups (28.4 mu/l) (P 0.015). Of the PPH cases none had symptomatic hypoglycaemia. Three PPH cases with cortisol < 500 nmol/l underwent short synacthen test (SST); 2 had a cortisol post-SST > 550 nmol/l. One patient showed suboptimal response with a cortisol level at 416 nmol/l and is undergoing further investigation. There were no differences between groups in body mass index (median 22.1 kg/m2) or lung function. PPH occurred in 19% of the cohort and was associated with detectable insulin at the 2 hour OGTT timepoint, suggesting the possibility of dysregulated insulin release. AGT patients had higher insulin levels than NGT cases, suggesting relative rather than absolute insulin deficiency in this cohort of PWCF.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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