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Endocrine Abstracts (2017) 49 EP434 | DOI: 10.1530/endoabs.49.EP434

ECE2017 Eposter Presentations: Diabetes, Obesity and Metabolism Diabetes (to include epidemiology, pathophysiology) (95 abstracts)

The importance of islet antigen-2 and glutamic acid decarboxylase antibodies in proper diagnosis of diabetes mellitus at the age ≥30 and <70 years

Aiste Kondrotiene 1 , Evalda Danyte 2, , Rimantas Zalinkevicius 3 & Rasa Verkauskiene 2,


1Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania; 2Department of Endocrinology, Kaunas clinics, Hospital of Lithuanian University of Health Sciences, Kaunas, Lithuania; 3Institute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.


Objective: Misclassification of type 1 (T1DM) and type 2 diabetes mellitus (T2DM) is quite common and crucial to choice of appropriate therapy. The aim of the study was to evaluate the correspondence of islet antigen-2 (Anti IA2) and glutamic acid decarboxylase (Anti GAD65) antibodies with clinical diagnosis.

Methods: The Anti IA2 and Anti GAD65 were measured in 583 patients (337 males and 246 females) diagnosed with T1DM or T2DM with not typical manifestation at the age ≥30 and <70 years. The data for analysis was collected from medical files.

Results: 245 (42.02%) cases had primary diagnosis of T1DM, and 338 (57.98%) – T2DM. One or both positive antibodies were found in 271 patients (group I), and all negative in 312 (group II). The mean age at onset of diabetes mellitus was 42.55±9.29 yrs in group I vs. 41.83±8.53 yrs in group II; P=0.33. One or both antibodies were found in 141 patients with primary diagnosis of T1DM (odds ratio (OR) 1.84 (95% CI 1.69–2.01, sensitivity 57.55%), 77 males (OR 0.92 (95% CI 0.83–1.04, sensitivity 49.01%) and 27 females (OR 6.16 (95% CI 5.34–7.11, sensitivity 71.28%). 208 patients with T2DM had negative antibodies (OR 2.56 (95% CI 2.38–2.77, sensitivity 61.54%), 63 males (OR 3.81 (95% CI 3.45–4.22, sensitivity 66.13%), and 67 females (OR 1.61 (95% CI 1.44−1.81, sensitivity 71.28%).

Conclusion: The presence of antibodies corresponded to primary diagnosis in 49.01% to 71.28% at the age ≥30 and <70 years.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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