Endocrine Abstracts (2017) 49 EP735 | DOI: 10.1530/endoabs.49.EP735

Gestational diabetes risk in three Israeli population subgroups

Anat Jaffe1, Shmuel Giveon2, Carmit Rubin3, Ilia Nvokov3, Arnona Ziv3 & Ofra Kalter-Leibovici2,3

1Hillel Yaffe Medical Center, Hadera, Israel; 2Sackler School of Medicine, Tel Aviv, Israel; 3Gertner Institute for Epidemiology and Health Policy Research, Ramat Gan, Israel.

Objective: Israeli Ethiopian Jews (EJ) and Arabs have at reproduction age higher incidence of diabetes than other Israeli Jews. We aimed to compare gestational diabetes (GDM) risk among these population subgroups.

Methods: The study cohort included age-matched EJ, non-Ethiopian Jews (NEJ) and Arab women age 20–45 years. GDM diagnosis was based on the two step screening method of 50 and 100 g oral glucose load tests. Univariate comparisons and the association between population subgroups and the risk for GDM were tested in multiple logistic regression analysis, adjusted for age, parity and pre-gestational levels of the metabolic syndrome components.

Results: The study included 13 943 women (2938 EJ, 5156 NEJ and 5849 Arabs). During the years 2008–2011, birth rate was 0.358, 0.475 and 0.526 (P<0.001), diabetes screening was performed in 84, 81, 85 and GDM prevalence was 4.3, 2.2 and 2.9% among Ethiopian, non-Ethiopian and Arab women respectively. The multivariate odds ratios (OR) for GDM were age 2.9-per 10 years (95% CI 2.1–4.1), BMI 1.12 (95% CI 1.1–1.2), triglycerides 1.05-per 10 mg/ml (95% CI 1.0–1.1), systolic blood pressure 1.05-per 10 mmHg (95% CI 1.02–1.1), parity 0.8 (95% CI 0.7–0.9) and Ethiopian ethnicity 2.55 (95% CI 1.6–4.1). Arab-ethnicity 1.4 (95% CI 0.95–2.15) and HDL-c 0.99 (95% CI 0.91–1.08) were not associated with risk for GDM.

Conclusions: Ethiopian ethnicity is an independent risk for GDM. The higher GDM prevalence in Arab women is mainly explained by higher obesity rates.

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