Diabetes melliuts (DM) presents particular challenges after kidney transplant (KT). These challenges contribute to cardiovascular disesases among diabetic recipients. We assessed frequency of posttransplant cardiovascular events in diabetic patients.
Methods: This retrospective study conducted in 399 kidney recipients at our center. The patients were divided into two groups: DM (n:59, 52.5% females) and non-DM (n:340, 46.5% females).
Results: The median KT duration was 4 years. The median age and BMI of DM group were higher than those of non-DM group (51 vs 42 years and 28.6 vs 25.8 kg/m2, respectively, P<0.001). The mean creatinine levels of both groups were similar. Hypertension (76.3 vs 62.4%, P=0.04), coronary artery disease (15.3 vs 4.1%, P=0.001), obesity (39.7 vs 20.9%, P=0.007) and dyslipidemia (32.3 vs 15.4%, P=0.002) co-morbidities in DM were more frequent than those of non-DM groups. There was no significant difference between the ratios of myocardial infarction (3.4 vs 2.6%), cardiac arrhythmia (3.4 vs 9.4%), congestive heart failure (3.4 vs 1.2%), stroke (1.7 vs 0.6%), transient ischemic attack (1.7 vs 4.1%) and peripheral vascular disease (3.4 vs 0.6%) in DM and non-DM groups. The ratio of patients underwent angioplasty was higher than that of non-DM group (23.7 vs 12.1%, P=0.016) while the ratios of patients underwent coronary stenting (1.7 vs 1.8%) and coronary by-pass operation (3.4 vs 1.2%) were similar. The graft loss and mortality rates in DM and non-DM groups did not differ (5.1 vs 5.6% and 5.1 vs 1.8%, respectively).
Conclusion: We observed that there was no difference in new cardiovascular events, graft loss and mortality between recipients with or without DM after KT.
20 - 23 May 2017
European Society of Endocrinology