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Endocrine Abstracts (2017) 49 EP944 | DOI: 10.1530/endoabs.49.EP944

Pituitary - Clinical

Acromegaly and cardiovascular risk

Betina Biagetti1, Anna Aulinas2, Natividad Lopez1, Esther García-Fernandez1, Maria José Arnau-Vives1, Andrea Ciudin1, Gabriel Obiols1, Belen Dalama1 & Jordi Mesa1

1Vall d’Hebron Hospital, Barcelona, Spain; 2Hospital Universitari de Vic, Barcelona, Spain.

Background: Acromegaly (ACRO) is associated with increased cardiovascular morbidity and mortality, however, there is no evidence of an increase in ischemic heart disease in these patients. We hypothesized that non-classical cardiovascular risk factors such as epicardial fat (EF), interventricular septum thickness (IST), carotid intima-media thickness (CIMT), may be increased in ACRO and contribute to this higher cardiovascular morbidity.

Objective: To evaluate EF, IST, and CIMT in patients with ACRO compared to controls and identify possible predictors in this non-classical cardiovascular risk factors.

Material and methods: We studied CIMT, IST, EF in 30 patients with ACRO (16 males, 5 with active disease) and 30 matched controls (by age, sex and body mass index (BMI)).

Results: Both cohorts were identical regarding the presence of cardiovascular risk factors (CVRF. The ACRO cohort presented higher EF and IST compared to the control group (0.65±0.16 vs 0.43±0.14 cm, P=0.001 and 11.31±1.17 vs 10.64±1.47 mm, P=0.035, respectively). The presence of ACRO (ß 0.545, P<0.001; R2 297) was the unique positive predictor of EF, while BMI and hypertension were positive predictors of IST (ß 0.379, P=0.006 and ß 0.344, P=0.013, respectively, R2 0.298) in a multiple linear regression model.

Conclusions: Patients with ACRO have higher EF and higher IST (influenced by hypertension and BMI), compared with matched controls despite a similar prevalence of CVRF. Increased EF and IST could partially contribute to this increased cardiovascular morbidity and mortality observed in acromegaly.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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