Endocrine Abstracts (2017) 49 EP985 | DOI: 10.1530/endoabs.49.EP985

Venous glucose levels, peak GH and peak cortisol during Insulin Tolerance Test using 0.15 UNITS/Kg and 0.1 UNITS/Kg body weight

Phillip Yeoh1, Ashley Grossman2,1, Shern L Chew1, Pierre Bouloux3,1, Bernad Khoo3,1, Paul Carroll4,1, Simon Aylwin5,1 & Stephanie Baldweg6,1

1The London Clinic, London, UK; 2John Radcliffe Oxford, Oxford, UK; 3Royal Free Medical School, London, UK; 4Guys & St Thomas Hospital, London, UK; 5Kings College Hospital, London, UK; 6UCLH Hospitals, London, UK.

Insulin Tolerance Test (ITT) is a procedure commonly done by Endocrine Specialist Nurse in endocrine department. We look at over 120 ITT results done in 2 endocrine centres using Insulin Actrapid 0.15 UNITS/kg and 0.10 UNITS/kg dose plotting the glucose levels at 30, 45 and 60 min. We also look at peak GH and peak cortisol on each of these groups.

Aims: We wanted to know how many percentage of patients achieving hypoglycaemia below 0.5 mmol/l, 0.5–1.0 mmol/l, 1.1–1.5 mmol/l, 1.6–2.0 mmol/l and above 2.0 mmol/l. We also look at percentage of peak GH response achieving over 9 microgram/l, between 8–9 microgram/l and below 8 microgram/l. In the peak cortisol response, we looked at results over 550 nmol/l; 500–550 nmol/l; 450–500 nmol/l; 400–450 nmol/l and below 400 nmol/l. Within these data, we also look at a small groups of results for patients’ using 0.15 UNITS/kg as repeat dose and repeat ITT using the lower dose to compare if these are difference in these markers.

Summary: We are unable to draw summary at the moment as well still got 30 data to go through.

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