Objective: Triglyceride glucose (TyG) index is considered a surrogate marker of insulin resistance, and insulin resistance is known risk factor of cardiovascular disease. Until now, few studies have investigated the relationship between TyG index and coronary artery calcification (CAC), thus we investigated the correlation between TyG index and CAC in healthy Korean Adults.
Methods: A total of 4,463 participants underwent cardiac computed tomography in health promotion center were enrolled. TyG index was calculates as ln[fasting triglycerides(mg/dl) X fasting glucose(mg/dl)/2]. Multi-detector CT was used to measure coronary artery calcium score (CACS) and CACS>0 was defined as the presence of CAC.
Results: There were significant differences in cardiovascular parameters among the groups and the prevalence of CAC significantly increased with TyG index levels. In the logistic regression analysis after adjusted for multiple risk factors, the odds ratios (95% CI) for the prevalence of CAC were 1.0, 1.03 (0.721.45), 1.23 (0.851.74), 1.68 (1.152.44) for increasing TyG index level (P<0.05).
Conclusion: There was a significant association between TyG index and prevalence of CAC. TyG index, a simple measure reflecting insulin resistance, might be useful to the indicator of atherosclerosis. TyG index is even simple to calculate and seems a useful marker of atherosclerosis, and reflect cardiovascular risk.
20 - 23 May 2017
European Society of Endocrinology