Endocrine Abstracts

Annexin A1 (AnxA1), a Ca2+ and phospholipid binding protein, is a mediator of glucocorticoid (GC) action in the neuroendocrine and host defence systems. It acts at least in part via members of the membrane bound formyl peptide receptor (Fpr) family, particularly Fpr2 which is also a target for the anti-inflammatory eicosanoid, lipoxin A4, as well as pro-inflammatory bacterial formylated peptides. Unregulated inflammation underlies many diseases, including...