Endocrine Abstracts

Chemotherapy and radiotherapy can both cause ovarian failure, and radiotherapy can also damage the uterus increasing the risk of miscarriage and premature delivery. Alkylating agents are recognised to be the most gonadotoxic class of chemotherapeutic agents, but treatment regimens often involve multiple drugs complicating assessment of effect and risk. The prepubertal reproductive system is also sensitive to these effects, although age, with treatment regimen, are important de...

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Cancer and treatments for cancer can have a significant impact on bone health in both children and adults. There are emerging data that bone mineral density is often reduced in survivors of childhood cancers and survivors of both solid tumours and haematological malignancies in adults. Fracture rates in childhood cancer survivors have not been shown to be increased. Older adult cancer survivors, particularly those treated with aromatase inhibitors and androgen deprivation ther...