Endocrine Abstracts

Thyroid hormone is a major determinant of tissue functions in vivo. Within the tissues, cells are not passive players in the process of hormonal signaling since they can actively customize hormonal action. Triiodothyronine (T3), the active form of thyroid hormone is produced predominantly outside the thyroid parenchyma secondary to peripheral tissue deiodination of thyroxine (T4), with <20% being secreted directly from the thyroid. Upon entering the cells via specific tran...