Endocrine Abstracts (2017) 50 CMW3.4 | DOI: 10.1530/endoabs.50.CMW3.4

How do I . . . . manage thionamide induced leucopaenia

Tristan Richardson


Royal Bournemouth Hospital, Bournemouth, United Kingdom.


The presentation will start with a review of the relationship with autoimmune thyrotoxicosis and the white cell count. Pre-therapy measurements and on-going measures of checking for leucopenia will be discussed.

The evidence for a temporal effect of the thionamides will be reviewed. This will detail the times for increased vigilance and appropriate standard advice for patients initiating thionamides. Dosing and different thionamides and their potential varying effects will be presented. The pros and cons of switching medications will be analysed and potential alternatives?

The management of acute leucopenia with associated sepsis secondary to thionamides will then be discussed with inpatient management of the acutely unwell leucopenic patient, with personal observations and best practice described. Options for the unresponding patient will be discussed, from an evidence based perspective and presentation of alternate options that may be useful in managing your next patient with thionamide induced leucopenia.

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