Aim: We aimed to investigate mortality and morbidity in patients who were identified with primary hypoparathyroidism, post-surgical and non-surgical hypoparathyroidism.
Methods: The patients who were previously identified with hypoparathyroidism, were linked to hospital admission dataset, renal registry, biochemistry dataset and prescribing dataset. In this study, death and 6 morbidities; cataract, circulatory system, infection, fracture, mental health disorders and eGFR were identified through OPCS and ICD codes. The percentage of each outcome after diagnosis of hypoparathyroidism were compared between post-surgical and non-surgical hypoparathyroidism groups. Patients were separated into two age groups; <60 and $ 60 years old for this analysis. The mean and median duration from time of diagnosis to outcome were measured. Chi-squared test was used to compare the percentage of each event between the two groups.
Results: There were 222 patients who were previously identified with primary hypoparathyroidism, 116 with post-surgical and 106 with non-surgical hypoparathyroidism. The mean age of the patients was 48.7 years (SD: 19.0) and 72.5% of patients were female. The mean duration of follow-up from time of diagnosis till end of study was 14.7 years (SD: 8.8). The overall rates of death, circulatory disease and mental health disorders among these patients were 28.4%, 32.0% and 51.8% respectively. In patients who were below 60 years old, there were significantly higher percentage of circulatory disease (P=0.024) and death (P=0.019) in the non-surgical hypoparathyroidism group compared to the post-surgical group. However, in patients who were 60 and above, there were significantly higher percentage of death (P=0.012) and eGFR lesser than 30 ml/min/1.73 m2 (P=0.001) in the non-surgical group.
Conclusion: Patients with hypoparathyroidism had high rates of circulatory disease, mental health disorders and death. Circulatory diseases, renal failure and death were more common in non-surgical hypoparathyroidism than in post-surgical hypoparathyroidism.