Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2017) 51 P027 | DOI: 10.1530/endoabs.51.P027

BSPED2017 Poster Presentations Miscellaneous/other (16 abstracts)

Is there an association between endocrine conditions, including growth hormone deficiency, and Chiari-1 Malformation? A retrospective single centre study

Sabba Elhag , Jamie Shah , Ruth Krone , Melanie Kershaw , Nick Shaw , Timothy Barrett , Jeremy Kirk , Vrinda Saraff , Wolfgang Hogler , Guirish Solanki & Renuka Dias


Birmingham Children’s Hospital, Birmingham, UK.


Introduction: Chiari-1 malformation (C-1M) is defined as the crowding of the craniocervical junction as a result of congenital cerebellar tonsil descent past the foramen magnum. Reported association between endocrine disorders and C-1M is mostly anecdotal.

Aims: To evaluate the prevalence of endocrine disorders in C-1M against the prevalence of C-1M in those with isolated Growth Hormone Deficiency (GHD) with the aim of determining if there is a significant association.

Methods: We undertook a retrospective study of all patient cases under paediatric endocrinology at our hospital with confirmed C-1M since June 2002 (N=20). This was compared to the number of patients under treatment for isolated GHD and found to have C-1M. Bar demographics and co-morbidities including endocrine abnormalities, the following data points were reviewed: age at/method of diagnosis, height/weight centiles, velocity, mid parental/final height, and endocrine function (baseline and on dynamic function testing).

Results: 21 cases were identified as suspected C-1M. N=20 had MRI confirmation and N=1 was excluded. 40% (N=8) had GHD with treatment, 15% (N=3) had GHD and short stature and a separate 20% (N=4) had idiopathic short stature (ISS). This totalled 60% (N=12) with either GHD or ISS. Other endocrine conditions found included pan-hypopituitarism, hypophosphatasia, precocious puberty, undescended testes, polycystic ovarian syndrome, osteoporosis, vitamin D deficiency and fasting hyperinsulinemia (N=1 per condition). 20% (N=5) were obese, which was not unexpected given 25-33% of UK children are obese. N=848 patients were identified as requiring growth hormone injections since 2007. Of these, an additional N=2 patients had C-1M that were not in our original cohort.

Discussion: Less than 1.2% of patients with GHD were diagnosed with C-1M. Therefore, there would not appear to be a significant association between endocrine dysfunction and C1-M although further studies into the entire C1-M cohort need to be done.

Volume 51

45th Meeting of the British Society for Paediatric Endocrinology and Diabetes

British Society for Paediatric Endocrinology and Diabetes 

Browse other volumes

Article tools

My recent searches

No recent searches.