Endocrine Abstracts (2018) 53 OU2 | DOI: 10.1530/endoabs.53.OU2

Novel therapies for obesity - an update

Tricia Tan


Imperial College Healthcare NHS Trust, London, UK.


Obesity surgery is not a scalable solution for obesity and diabetes. Options for pharmacotherapy are sorely required because there will be patients who cannot and will not have surgery, or perhaps will require a ‘bridge’ to surgery. Although oral agents such as Orlistat and Bupropion/Naltrexone are marketed in Europe, these treatments suffer from considerable side effects that limit their appeal and efficacy. Gut hormone treatments, exemplified by high-dose Liraglutide (Saxenda) and Semaglutide, are now coming into the market. These take advantage of physiological satiety and metabolic pathways. However, even high-dose Liraglutide has limited efficacy and there is a significant percentage of patients who do not respond. This presentation will look at the concept of multiple/combination gut hormones as practicable treatments for diabetes and obesity.

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