NuclearReceptors2018 Invited Speaker (1) (14 abstracts)
Nuclear receptor networks in male fertility
Emmanuelle Martinot , Lauriane Sèdes , Marine Baptissart , Hélène Holota , De Haze Angélique , Claude Beaudoin & David H Volle
Inserm U 1103, CNRS UMR6293–Université Clermont Auvergne, Laboratoire Génétique, Reproduction & Développement, Clermont-Ferrand, France.
Male fertility is controlled by complex interactions between hypothalamus, pituitary, and testis. The major functions of the testis include production of spermatozoa and synthesis of hormones. Testosterone is produced by the testicular Leydig cells and ensures male fertility. Testosterone is involved in the development of gonad, the attainment of puberty, the maintenance of secondary sexual characteristics as well as in spermatogenesis process. Many studies have highlighted the complexity of the regulations of testicular homeostasis at tissue and cellular levels. Several nuclear receptors (NRs) have been identified as key regulators of testicular physiology through the control of steroidogenesis and germ cell differentiation. Using both genetic and pharmacologic strategies the roles of the multiple members of the NR superfamily such as the Liver-X-Receptors, the Small Heterodimer Partner and more recently the Farnesol-X –Receptor have been defined. We will give an overview of recent advances highlighting the identification of a complex networks showing the interactions of NRs in the regulation of the exocrine and endocrine functions of the testis.
DOI: 10.1530/endoabs.54.IS12
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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