Endocrine Abstracts

Context: Aberrant CD4+T cell function plays a critical role in the process of Graves’ disease (GD). MicroRNAs (miRNAs) are important regulators of T cell activation, proliferation and cytokine production. However, the contribution of miRNAs to CD4+T cell dysfunction in GD remains unclear.Objective: To investigate how certain miRNA causes aberrant CD4+T cell function in GD patients.Methods: We compared the expression pattern of...

Introduction: Hyperthyroidism is a prevalent condition which affects approximately 2% of the female population and 0.2% of the male population in the UK. 75% of cases are caused by the auto-immune condition, Graves’ disease. Thyrotropin receptor antibodies (TRAb) are raised in 90% of patients with Graves’ disease and are commonly used to investigate the aetiology of thyrotoxicosis.Background: TRAb can be used to confirm Graves’ disease due...

Background: An association of pregnancy outcomes with subclinical hypothyroidism have been reported, however, there still exists a strong controversy regarding whether subclinical hypothyroidism ought to be dealt with or not. The latest American Thyroid Association’s guideline gives support to a higher TSH upper reference range of 4 mIU/l than the one proposed a few years ago of 2.5 mIU/l for the first trimester of pregnancy, in the absence of local normal ranges of TSH. ...

Introduction: Thyroid antiperoxidase antibodies above the cut-off value (ATPO +) may increase the risk of maternal-foetal complications and could modify the treatment criteria. The aim of the study is to consider the impact of levothyroxine administration on maternal-foetal complications in ATPO+ pregnant women with delivery in 2016.Methods: In Leon’s health area (Spain), universal screening for gestational thyroid dysfunction is performed. ATPO + w...

The use of immune checkpoint inhibitors (ICPI) for treatment of different advanced cancers has opened a new therapeutic window. Thyroid dysfunction is an often side effect described for these drugs.Objectives: To describe the thyroid alterations found in oncologic patients undergoing treatment with ICPI.Materials and methods: A descriptive, retrospective study of oncologic patients receiving treatment with ICPI referred to the Endo...

Background: Thyroid eye disease (TED) is an autoimmune inflammatory disease that can be both disfiguring and potentially sight threatening. Suppression of inflammation in active disease can reduce the risk of visual loss and limit long-term sequelae of the disease. Current disease management involves suppression of inflammation using glucocorticoids. The aim of our study was to evaluate the efficacy of early disease intervention with targeted immunomodulatory therapy to alter ...

Immunoglobulin G4-related disease (IgG4-RD) is a newly identified syndrome characterized by high serum IgG4 levels and increased IgG4-positive plasma cells infiltration. IgG4-related thyroiditis (IgG4-RT) was first prescribed based on the immunohistochemistry in 2009. Some of Hashimoto’s thyroiditis (HT), Graves’ disease (GD) and Riedel thyroiditis were reported to be classified as IgG4-RT based on high serum IgG4 level or histopathological findings. However, the pre...

Objective: Immune checkpoint inhibitors (ICPI) have become an effective therapeutic option for certain advanced malignant tumours. Immune-related adverse events affecting thyroid function are among the most frequent toxicities. The aim of our study is to determine the prevalence of thyroid disorders in patients undergoing treatment with ICPI.Methods: Retrospective study including all patients treated with ICPI in our centre, from 07/2015 to 12/2017. Pati...

Introduction: Autoimmune thyroid disease is associated with other autoimmune diseases. However, most studies are register-based cohort studies or investigate selected patient populations. In a large national cross-sectional population-based study, we investigated positivity of thyroid peroxidase- or thyroglobulin-antibodies (TPOAbs or TgAbs) in association with non-thyroidal autoimmune disease.Methods: As part of The Danish Investigation of Iodine Intake...

Objectives: The interplay between thyroid function and metabolic state has been studied in many population subgroups. For pregnant women thyroid and metabolic parameters, including glucose homeostasis, are of great importance for a successful outcome. We examined aspects of thyroid function in relation to GDM and BMI in pregnant women referred to our Department.Methods: We studied 520 women during 24th – 32nd gestation week. De...