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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Poster Presentations: Adrenal and Neuroendocrine Tumours

Adrenal cortex (to include Cushing's)

ea0056p1 | Adrenal cortex (to include Cushing's) | ECE2018

Congenital adrenal hyperplasia in lady with severhirsutism and virilization due to 3B-hydroxysteroid dehydrogenase deficiency

Qari Faiza

A 30-year-old woman pakistani patient was admitted to king Abdulaziz University hospital in Jeddah, Saudi Arabia with history of severe abdominal pain, vomiting and hypotension. She was born with Ambiguous genitalia and operated at age 8 years. She has severe hirsutism, with score of 18 and virilization. There are no family history of congenital adrenal hyperplasia. Physical examination showed her height was 151 cm and weight 42 kg. For evolution of hirsutism and virilization....

ea0056p2 | Adrenal cortex (to include Cushing's) | ECE2018

Endogenous stimulation in adrenal venous sampling (AVS) in differential diagnosis of primary hyperaldosteronism (PA)

Rybakova Anastasia , Sitkin Ivan , Kolesnikova Galina , Platonova Nadezda , Troshina Ekaterina , Romanova Natalia , Beltsevich Dmitry

Relevance: Due to numerous causes of PA, AVS allows differentiating variant nosological forms of PA. The importance of differential diagnosis is due to the fact that surgery is reasonable only with unilateral variant of PA, while in idiopathic hyperaldosteronism surgery isn’t a method of choice.Purpose: To assess the diagnostic possibilities of using AVS against the background of endogenous stimulation of adrenocorticotropic hormone (ACTH) in the ea...

ea0056p3 | Adrenal cortex (to include Cushing's) | ECE2018

Congenital adrenal hyperplasia in 46xx male

Salem Mona , Haddad Hemmat El , Yousief Elham , Assem Maha , Salam Randa

Disorders of sex development create medical and social dilemma. Maleness with XX genotype is a rare genetic condition affecting one in 24,000 new-born males. Characterized by a spectrum of clinical presentation, ranging from normal male genitalia to ambiguous sex.Case report: A 31 years old patient with ambiguous genitalia raised as a male. He came to our endocrinology clinic to stabilize his male identity by surgical correction, no parental consanguinit...

ea0056p4 | Adrenal cortex (to include Cushing's) | ECE2018

Diagnostic difficulties of Pseudo-Cushing states in women: about 24 cases

Lassoued Najoua , Hasni Yosra , Kacem Maha , Chaieb Molka , Maaroufi Amel , Ach Koussay El

Introduction: Differentiation between mild Cushing’s syndrome (CS) and Pseudo-Cushing syndrome (PCS) can be extremely difficult. A Pseudo-Cushing state can be defined as a part or all of the clinical features that resemble a true CS with some evidence of hypercotisolism but the resolution of the underlying primitive state results in the disappearance of this Cushing state-like. The aim of this work was to describe the diagnostic difficulties of 24 cases of PCS.<p clas...

ea0056p6 | Adrenal cortex (to include Cushing's) | ECE2018

Is adrenocortical carcinoma in children a different spectrum?

Mayilvaganan Sabaretnam , Mishra Anjali , Agarwal Gaurav , Agarwal Amit , Mishra SK

Background: Adreno cortical carcinoma (ACC) is a rare malignancy associated with aggressive biological behavior and poor outcome. The reported incidence in literature is about approximately two cases per million population’s.These tumors might be functional or non-functional depending on their ability to secrete various adrenocortical hormones. ACC occurring in children and adults show distinct characteristics and there is not much literature regarding the differences. Si...

ea0056p7 | Adrenal cortex (to include Cushing's) | ECE2018

Travelling distance and support group participation in patients with chronic adrenal insufficiency

Dolle Michael , Schneidewind Sabine , Memmesheimer Rodica Mia , Manns Michael Peter , Terkamp Christoph , Leitolf Holger , Zender Steffen

Adrenal crisis is a life-threatening complication in patients with adrenal insufficiency. In order to prevent critical situations, patients have to increase their glucocorticoid dose in distressing situations. Continuous education of patients concerning dosage adaption in challenging situations seems to be important for long term management. As previously shown, both acute illness and emotional stress may lead to critical situations. In every outpatient visit patients should b...

ea0056p9 | Adrenal cortex (to include Cushing's) | ECE2018

Evaluation of tumor size and hormonal status of elderly with adrenal incidentaloma

Sarac Fulden , Savas Sumru , Tutuncuoglu Pelin

Incidentalomas (AI) are clinically inapparent adrenal masses. Patients present hormone excess or mass effect, but part of them is clinically silent. They are discovered inadvertently in the course of diagnostic testing or treatment for other clinical conditions. The aim of the study was to investigate the clinical value of tumor size and hormonal status of elderly patients with adrenal incidentaloma (AI).Subjects and Methods: Forty-four elderly with AI w...

ea0056p10 | Adrenal cortex (to include Cushing's) | ECE2018

Evaluation of adrenal function in Cushing’s syndrome model rats

Seki Toshiro , Yasuda Atsushi , Kitajima Natsumi , Seki Masami , Oki Masayuki , Fukagawa Masafumi

Cushing’s syndrome is caused by cortisol-secreting adrenocortical adenoma. Surgical resection of cortisol-secreting adenoma results in secondary adrenal insufficiency in most cases. The main mechanism of adrenal insufficiency is that the residual adrenocortical tissue becomes atrophied as a result of chronic suppression of the hypothalamic-pituitary-adrenal (HPA) axis by excessive cortisol levels. Therefore, we have analyzed Cushing syndrome model rats following the previ...

ea0056p11 | Adrenal cortex (to include Cushing's) | ECE2018

Does Hemodialysis (HD) affect the overall testosterone (T) and luteinizing hormone (LH) levels in T-treated hypogonadal Congenital Adrenal Hyperplasia (CAH) male with associated chronic kidney disease (CKD)? A pilot single center matched case report

Gluvic Zoran , Lackovic Milena , Samardzic Vladimir , Jevtic Jelena Tica , Vujovic Marina , Mitrovic Bojan , Popovic-Radinovic Vesna , Mladenovic Violeta , Kusic Jovana , Markovic Rodoljub , Jemcov Tamara , Isenovic Esma R.

Introduction: CAH is among the most common inherited metabolic disturbances, caused by Ar mutations of genes that encode enzymes involved in the adrenal steroids synthesis. Male hypogonadism and CKD can complicate the course of CAH. Additionally, HD can influence the CAH management by unpredictable effects of ultrafiltration on the levels of administered drugs. The aim of our study is to demonstrate the influence of HD on LH/T levels of eugonadal male as well hypogonadal male ...

ea0056p12 | Adrenal cortex (to include Cushing's) | ECE2018

A rare case of Cushing’s syndrome due to adrenal adenoma complicated by familial adenomatous polyposis

Ebashi Chihiro , Ono Noritaka , Hata Yasuhiro , Harada Hiroshi , Yamada Takayoshi , Sugano Hisashi

Introduction: Adrenal adenoma is one of the extraintestinal lesions associated with familial adenomatous polyposis (FAP). Only four cases of Cushing’s syndrome due to adrenal adenoma complicated by FAP, including ours, have been reported to date.Case report: A 37-year-old woman presented with pretibial edema and hirsutism. She was diagnosed with FAP at 8 years old. She had undergone resection of craniopharyngioma at 10 years old and repeated removal...

ea0056p13 | Adrenal cortex (to include Cushing's) | ECE2018

Hypoglycemic coma as first manifestation of primary adrenal insufficiency in a septic patient with severe hypokalemia and hypomagnesemia

Chrysoulaki Maria , Daraki Vasiliki , Betsi Grigoria , Sfakiotaki Maria , Dolapsaki Maria , Liarigkovinos Theodoros , Stylianou Kostas , Samonis George

Introduction: Adrenal crisis due to primary adrenal insufficiency may result in severe morbidity and mortality if undiagnosed or ineffectively treated. Main manifestations are hypotension (>90%), hyponatremia (70–80%), and hyperkalemia (30–40%), while hypoglycemia is rare. An unusual case of a septic patient with hypokalemia and hypomagnesemia with hypoglycemic coma as first manifestation of acute adrenal insufficiency is presented.Case pre...

ea0056p14 | Adrenal cortex (to include Cushing's) | ECE2018

Preoperative treatment with metyrapone in patient with Cushing’s syndrome due to adrenal adenoma: a pilot prospective study

Puglisi Soraya , Perotti Paola , Barbot Mattia , Cosio Paolo , Scaroni Carla , Stigliano Antonio , Lardo Pina , Morelli Valentina , Polledri Elisa , Chiodini Iacopo , Reimondo Giuseppe , Pia Anna , Terzolo Massimo

Background and objectives: Metyrapone has been approved for the treatment of patients with Cushing’s syndrome from all causes, but only few retrospective clinical studies are available. The aim of our study was the prospective assessment of metyrapone as pre-operative treatment.Methods: Before adrenalectomy, 7 patients with ACTH-independent Cushing’s syndrome due to adrenal adenoma were prospectively treated with metyrapone for 3 months, with e...

ea0056p15 | Adrenal cortex (to include Cushing's) | ECE2018

Clinical features of adrenal incidentalomas

Radojkovic Danijela , Pesic Milica , Radojkovic Milan , Kostic Sonja , Curkovic Sanja , Radenkovic Sasa , Ciric Vojislav , Antic Slobodan

Introduction: Adrenal incidentalomas (AI) are tumours revealed during radiological procedures in patients without previous suspicion for adrenal disease. This study was conducted to determine the frequency of functional AI.Patients and methods: Thirty-eight patients with AI were included in the study. The following parameters were considered: patient age, gender, size and location of the tumour, and radiological characteristics of adrenal masses. In orde...

ea0056p16 | Adrenal cortex (to include Cushing's) | ECE2018

Rare incidence of primary adrenocortical carcinosarcoma: a case report

Maria Diaz Perdigones Cristina , Maria Cornejo Pareja Isabel , Damas Fuentes Miguel , Molina Vega Maria , Hernandez Garcia Carmen , Munoz Garach Araceli , Jose Tinahones Madueno Francisco

Introduction: Adrenal tumors are common tumors with a prevalence of around 3% in a population over the age of 50 years. In contrast, adrenocortical carcinoma (ACC) is a rare malignancy (incidence 1–2 per 1 million population) with a heterogeneous presentation and a variable but generally bad prognosis. Patients present with evidence of adrenal steroid hormone excess in approximately 60% of cases.Case report: A 49-year-old woman with symptoms of faci...

ea0056p17 | Adrenal cortex (to include Cushing's) | ECE2018

Clinical and biochemical outcomes in surgically treated patients with primary aldosteronism. A multicentric retrospective study

Vicente Almudena , Sirvent Alejandro , Herranz Sandra , Lamas Cristina , Martinez Ana , Sastre Julia

Background: Although unilateral primary aldosteronism (PA) is the most common surgically correctable cause of hypertension, no standard criteria exist to classify surgical outcomes. The Primary Aldosteronism Surgical Outcome (PASO) study was an international project to develop consensus criteria for outcomes and follow-up of adrenalectomy for unilateral PA.Objetives: To determine the proportions of patients achieving complete, partial, or absent clinical...

ea0056p18 | Adrenal cortex (to include Cushing's) | ECE2018

Intraoperative hypertensive crisis as a key symptom in a normotensive patient with primary aldosteronism – clinical case

Kuzior Agnieszka , Delia Santana-Suarez Ana , Esteban Nivelo-Rivadeneira Manuel , Fernandez-Trujillo-Comenge Paula , Arnas-Leon Claudia , Acosta-Calero Carmen , Quintana-Arroyo Sara , Javier Martinez-Martin Francisco

Primary aldosteronism is now recognized as the most frequent cause of secondary hypertension, accounting for 5–10% of the total cases of hypertension. Reportedly it is associated with a risk of cardiovascular events above and beyond hypertension development. Notwithstanding its high prevalence and serious complications, it is widely infradiagnosed. Hereby we present the case of a normotensive 50-year old female patient who was diagnosed of probable left hypernephroma, but...

ea0056p19 | Adrenal cortex (to include Cushing's) | ECE2018

Adrenal insufficiency during prednisolone treatment in patients with polymyalgia rheumatica or giant cell arteritis – prevalence and clinical approach

Willemoes Borresen Stina , Laursen Toke , Jensen Bente , Hilsted Linda , Marie Bartels Else , Feldt-Rasmussen Ulla , Locht Henning

Introduction: Prednisolone is standard treatment of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA), but many patients are reluctant to discontinue prednisolone treatment even after remission of the inflammatory conditions. Prednisolone-induced adrenal insufficiency can give manifest or latent symptoms, causing failure to taper and withdraw prednisolone. We therefore aimed to find the prevalence of adrenal insufficiency in prednisolone-treated patients with PMR/GCA...

ea0056p20 | Adrenal cortex (to include Cushing's) | ECE2018

Prevalance of primary aldosteronism in hypertensive patients: epidemiological data from a tertiary centre

Voulgaris Nikolaos , Papanastasiou Labrini , Vlachou Sofia , Kyriazi Evangelia , Tyfoxylou Ernestini , Monastirioti Nikoletta , Kapsali Chara , Charalampidou Liana , Aglaia Zachaki , Kalantzi Athanasia , Gravvanis Christos , Markou Athina , Giagourta Eirini , Kounadi Theodora , Kassi Eva , Kaltsas Gregory , Piaditis George

Introduction: Primary aldosteronism (PA) is the most common cause of endocrine hypertension. Its prevalence varies from 5-15%, which depends mainly on the cut-offs of the diagnostic tests.Aim: To estimate the prevalence of PA in patients with different stages of hypertension based on a dynamic overnight diagnostic test.Methods: One hundred ninety nine hypertensive patients were divided in 3 groups according to the stage of hyperten...

ea0056p21 | Adrenal cortex (to include Cushing's) | ECE2018

Renin: a possible novel marker for the efficacy of pharmacological treatment of primary aldosteronism

Voulgaris Nikolaos , Vlachou Sofia , Kyriazi Evangelia , Papaoikonomou Eleni , Tyfoxylou Ernestini , Monastirioti Nikoletta , Kapsali Chara , Zachaki Aglaia , Charalampidou Liana , Kounadi Theodora , Markou Athina , Papanastasiou Labrini , Giagourta Eirini , Kassi Eva , Kaltsas Gregory , Piaditis George

Introduction: Primary aldosteronism (PA) treatment is either pharmacological with aldosterone receptor antagonists (MRAs) or surgical with the resection of the responsible adenoma. The efficacy of MRAs treatment is based on the normalization of blood pressure (BP) in relation to potassium levels. However, it remains unclear whether the stimulation of renin levels during treatment could serve as an additional marker of adequate MR blockade.Aim: To investi...

ea0056p22 | Adrenal cortex (to include Cushing's) | ECE2018

Conn Syndrome Presented with Muscle Weakness

Alaguney Elif Sevil , Yorulmaz Goknur , Canaz Funda , Badak Bartu , Kebapci Nur

Introduction: Aldosterone producing adenoma, called Conn syndrome, accounts for 10 percent of all hypertension cases. It should be remembered in patients with hypokalemia and hypertension however, this is not a rule. Conn syndrome can be presented with hypertension but normal potassium levels. Also, rarely it can be presented with hypokalemia but normal blood pressure as in our case.Case report: 34-year-old female patient complained about difficulty in w...

ea0056p23 | Adrenal cortex (to include Cushing's) | ECE2018

Large Oncocytic Adrenocortical Tumor with Uncertain Malignant Potential

Buyruk Betul Aydin , Yorulmaz Goknur , Efe Belgin , Badak Bartu , Arik Deniz , Kebapci Nur

Introduction: Oncocytic tumor of adrenal gland was defined as a neoplasm composed exclusively or predominantly of oncocytes which are large and polygonal cells with eosinophilic cytoplasm because of abnormal accumulation of mithochondria. Oncocytic neoplasms of the adrenal cortex are extremely rare and are usually non-functioning, benign and incidentally detected.Case: A 40-year old male patient, for whom a large mass in the adrenal gland was diagnosed i...

ea0056p24 | Adrenal cortex (to include Cushing's) | ECE2018

Conjugated steroids could be a reserve stock for rapid conversion into free ones during stress

Duskova Michaela , Kolatorova Lucie , Simunkova Katerina , Kosak Mikulas , Hill Martin , Pospisilova Hana , Jandikova Hana , Sramkova Monika , Starka Luboslav

Hypoglycaemia stimulation serves as a model of physiological function of adrenal action during the stress reaction. The study aimed to describe the differences of steroid response between hypoglycemia and various doses of Synacthen (as ACTH stimulation alone). The goal of the study was to investigate the physiology of adrenal response. Twenty four steroids were measured in plasma using gas chromatography - mass spectrometry after stimulation of 1 μg, 10 μg and 250 &#...

ea0056p25 | Adrenal cortex (to include Cushing's) | ECE2018

Presence of comorbidities related to hypercortisolism in a case series on adrenal incidentaloma (AI)

Cesar Maria Jose Picon , Vega Maria Molina , Garcia Carmen Hernandez , Perdigones Cristina Diaz , Fuentes Miguel Damas , Madueno Francisco Tinahones

Introduction: The European Society of Endocrinology Clinical Practice Guideline defines follow-up recommendations for AI based on the 1 mg overnight dexamethasone suppression test and the presence of associated comorbidities. Follow-up is not recommended for AI presenting serum cortisol levels post dexamethasone ≤1.8 μg/dl neither those presenting serum cortisol levels post dexamethasone between 1.9–5 μg/dl (defined as ‘possible autonomous cortisol se...

ea0056p26 | Adrenal cortex (to include Cushing's) | ECE2018

Increased levels of Interleukin-6 in patients with primary and secondary hypocortisolism: A case-control study

Rahvar Amir-Hossein , Riesel Martin , Graf Tobias , Harbeck Birgit

Context: Hypocortisolism has been associated with increased cardiovascular risk (CVR) and mortality. Higher levels of certain inflammatory markers such as Interleukin-6 (IL6) in patients with adrenal insufficiency (AI) may partly explain the increase in CVR. Recent studies demonstrate an increased prevalence of cardiovascular disease (CVD) in patients with elevated IL-6 levels. Hypocortisolism is generally treated with glucocorticoid replacement therapy (GRT). Current GRT regi...

ea0056p27 | Adrenal cortex (to include Cushing's) | ECE2018

A new ARMC5 mutation responsible for primary bilateral macronodular adrenal hyperplasia

Mazarico Isabel , Subias David , Guitart Miriam , Bella Rosa Maria , Albert Lara , Luchtenberg Florencia , Berges Irene , Capel Ismael , Cano Albert , Casamitjana Laia , Gimenez-Palop Olga , Caixas Assumpta , Rigla Mercedes

Introduction: Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause (<2 percent) of endogenous Cushing’s syndrome, usually characterized by enlarged adrenal glands containing multiple functioning nonpigmented macronodules. PBMAH was thought to be sporadic, but recently a genetic component has been described. Specifically, inactivating mutations in ARMC5 (Armadillo-repeat containing 5), a suppressor gene, have been found in many familial c...

ea0056p29 | Adrenal cortex (to include Cushing's) | ECE2018

Secondary adrenal insufficiency – is not this diagnosis often made too hasty?

Papierska Lucyna , Nowak Karolina , Lebek-Szatanska Agnieszka , Juszczyszyn Marta , Glinicki Piotr , Zgliczynski Wojciech

Introduction: Isolated corticotropic insufficiency of hypophysis with consecutive secondary adrenal insufficiency is a very rare disease. Literature notes difficulties in proper recognition and necessity of differential diagnosis, including among others chronic fatigue syndrome. In recent years, in Poland we observe more and more frequently setting this diagnosis – only on the basis of low ACTH an cortisol concentrations, despite of proper stimulation with 250 μg<sup...

ea0056p30 | Adrenal cortex (to include Cushing's) | ECE2018

Assessing the new Primary Aldosteronism guidelines recommendation to omit confirmatory testing in selected patients – severity of hypokalaemia may be included

Tan Sarah , Zhang Meifen , Khoo Joan , Puar Troy

Background: Patients with an elevated aldosterone renin ratio (ARR) should proceed for a confirmatory test to diagnose primary aldosteronism (PA) before undergoing further investigations such as CT imaging and adrenal venous sampling. The recent 2016 clinical guidelines have included a new recommendation: that in the setting of spontaneous hypokalaemia, undetectable plasma renin, and plasma aldosterone concentration (PAC) >20 ng/dl, patients may not require further confirm...

ea0056p31 | Adrenal cortex (to include Cushing's) | ECE2018

Addison’s disease due to adrenal tuberculosis: A case report

Ozyurt Semih , Celik Ozlem , Unluoglu Gulsah , Celik Huseyin

During the past decades, incidence of adrenal tuberculosis has been greatly decreased due to the introduction of antituberculosis drugs. It is reported that primary adrenal insufficiency (PAI) results from adrenal tuberculosis accounting for only 15%–20% patients in developed countries. Adrenal tuberculosis is the major cause of chronic PAI especially in developing countries. A 53 year old man presented with a 3 month history of generalized weakness, anorexia, weight loss...

ea0056p32 | Adrenal cortex (to include Cushing's) | ECE2018

How can cortisol-normalized adrenal venous sampling miss some Conn’s adenoma

Duparc Elea , Constantinescu Georgiana , Ormezzano Olivier , Thony Frederic , Rodiere Mathieu , Baguet Jean-Philippe , Gomez-Sanchez Celsio , Fernandes-Rosa Fabio , Sturm Nathalie , Chaffanjon Philippe , Chabre Olivier

Introduction: In patients with primary aldosteronism (PA) international consensus claim that adrenal venous sampling (AVS) performs better than CT scan in determining lateralization of aldosterone secretion. The SPARTACUS study has however reported similar performances for lateralization by CT scan and AVS in patients with PA and a unilateral adrenal mass. The standard procedure for AVS uses cortisol values to validate the selectivity of catheterization and to normalize the al...

ea0056p33 | Adrenal cortex (to include Cushing's) | ECE2018

ACTH stimulation test for study of primary aldosteronism

Cunha Nelson , Gomes Leonor , Paiva Isabel , Oliveira Diana , Lages Adriana , Ventura Mara , Fadiga Lucia , Catarino Diana , Carrilho Francisco

Introduction: Primary aldosteronism (PA) is the principal cause of arterial hypertension potentially treatable. The diagnosis is dependent of tests to identify patients who will benefit most with surgical treatment. ACTH stimulation test (AST) has been described as a useful confirmatory test, potentially identifying bilateral disease in patients without adrenal tumors.Aim: Evaluate the AST in patients with hypertension and positive screening test for PA,...

ea0056p34 | Adrenal cortex (to include Cushing's) | ECE2018

Value of 131I-Norcholesterol scintigraphy in the evaluation of primary hyperaldosteronism

Casteras Anna , Villasboas-Rosciolesi Diego , Garcia-Burillo Amparo , Espinel Eugenia , Zafon Carles , Mesa Jordi , Castell-Conesa Joan

Background: 131I-norcholesterol scintigraphy (INCS) is currently not considered a main confirmatory and localizing study in primary aldosteronism (PA), however few recent data is available. On the other hand, adrenal venous sampling (AVS) is technically difficult, and may also lead to erroneuos diagnosis.Aim: To describe the performance of INCS, done under dexamethasone (DXM) supression, in daily practice.Patients and methods: Retr...

ea0056p35 | Adrenal cortex (to include Cushing's) | ECE2018

A four months infant survival case of waterhouse–friderichsen syndrome

Teodoriu Laura , Teodor Danut , Ungureanu Maria-Christina , Leustean Letitia , Ioan Bianca , Preda Cristina

Introduction: The Waterhouse–Friderichsen syndrome is a fulminating infection, often leading to mortality in a matter of hours by producing acute adrenal insufficiency (adrenal hemorrhage) at a time when their response is crucial to address acute stress.Case report: We present the case of a 4 months boy with high fever 40 °C, vomiting, diarrhea, lethargy, maculopapular rash followed by petechiae and purpura. Biological tests revealed important ...

ea0056p36 | Adrenal cortex (to include Cushing's) | ECE2018

Hypoaldosteronism induced by trimethroprim: hyponatremia is frequent

Herraiz Lorea , Azcutia Ane , Santiago Alejandro , Miguel Paz de , Crespo Irene , Cuesta Martin , Jimenez Ines , Calle Alfonso , Runkle Isabelle

Introduction: Hypoaldosteronism is characterized by the development of hyperkalemia, but can also induce hypovolemic hyponatremia. Trimethroprim can cause hypoaldosteronism through mineralocorticoid resistance. That hypoaldosteronism can induce hyponatremia in absence of Addison’s disease has been questioned. We studied the electrolyte disturbances found following initiation of trimetroprim therapy.Material and methods: Retrospective, analytical. La...

ea0056p37 | Adrenal cortex (to include Cushing's) | ECE2018

Utility of adrenal venous sampling for the differential diagnosis of primary hyperaldosternoism subtypes

Delegido-Gomez Laura , Miralles-Moragrega Raquel , Navarro-Hoyas Clara , Gonzalez Victoria , Sanchez-Blanco Fernando , Irurzun Javier , Serrano Joaquin

Introduction: In patients with primary hyperaldosteronism, distinguishing between unilateral and bilateral adrenal hypersecretion is critical in assessing treatment options. Adrenal venous sampling (AVS) has been advocated by some to be the gold standard for localization of the responsible lesion however is invasive, technically challenging, and difficult to interpret. Adrenal computed tomographic scanning (TC) is mandatory before AVS but more studies are warranted to identify...

ea0056p38 | Adrenal cortex (to include Cushing's) | ECE2018

Non-classic congenital adrenal hyperplasia clinics characteristics and treatment response cohort study

Lomba Alin Abreu , Santrich Melanie , Bermudez Claudia Gonzalez , Salazar Lina del Carmen , Muriel Ana Bolena , Gomez Milton , Hernandez Mauricio

Introduction: Non-classic congenital adrenal hyperplasia (NCCAH) is an autosomal recessive disorder, that affects adrenal steroidogenesis, and it is characterized by an enzymatic defect in corticosteroids biosynthesis. NCCAH diagnosis is based on the determination of 17a-hydroxiprogesterone (17a-OHP) basal levels, and levels after stimulation with adrenocorticotropic hormone (ACTH), and it is confirmed with molecular testing. Treatment is still controversial, and it must be in...

ea0056p39 | Adrenal cortex (to include Cushing's) | ECE2018

A rare incidentaloma: adrenal schwannoma

Dokmetas Hatice Sebile , Hincal Hande Ogul , Ozdenkaya Yasar , Kilicli Fatih , Saka Burcu

Introduction: Adrenal schwannoma is an extremely uncommon cause of incidentaloma. It originates from neural sheath Schwann cells of the adrenal gland. Herein, we report a case of left adrenal schwannoma that could not be diagnosed preoperatively.Case report: A 53 years old female morbid obese (BMI: 66.68 kg/m2) patient was referred to endocrinology policlinic because of 5 cm left adrenal mass detected on abdominal screening while preparing pat...

ea0056p40 | Adrenal cortex (to include Cushing's) | ECE2018

Cardiovascular risk in patient with incidentally detected adrenal masses – associated with metabolic syndrome and hypercortcism

Zivkovic Stanislava , Jelic Svetlana , Ivanovic Aleksandra Jevic

Background: Adrenal incidentalomas (AI) represent incidentaly discovered adrenal mases, without simptoms or signs suggestive of adrenal pathology, at the time of visualization. It is well-known that overt or subclinical hypercorticism, as well as metabolic syndrome (MetS) harbour increased CV risk.There is still persisting debate on eventual cause-effect relationship of AI with metabolic syndrome MetS or probability of simply more frequent occurance of AI among these patients....

ea0056p41 | Adrenal cortex (to include Cushing's) | ECE2018

Outcomes of patients undergoing surgery for primary aldosteronism based on adrenal venous sampling and/or radiological lateralisation indicate a role for both modalities in case selection

Davis Lauramay , Lewis Dylan , Clough Jennifer , Whitelaw Benjamin C , Gilbert Jackie , Diaz-Cano Salvador , Taylor David R , Vincent Royce P , Hubbard Jonathan , Galata Gabriele , Schulte Klaus-Martin , Aylwin Simon J B

Background: Adrenal venous sampling (AVS) is considered the gold standard for lateralisation of aldosterone production in patients with primary aldosteronism (PA). However, in some patients AVS is not technically successful and management may depend on radiological findings.Aim: To determine 1) the success rate of AVS and 2) the outcomes after surgery related to the lateralisation modality.Method: 156 patients were included who pre...

ea0056p42 | Adrenal cortex (to include Cushing's) | ECE2018

The response of C19- Δ5-steroids to ACTH stimulation

Pospisilova Hana , Duskova Michaela , Kolatorova Lucie , Kosak Mikulas , Hill Martin , Jandikova Hana , Simunkova Katerina , Sramkova Monika , Starka Luboslav

The adrenal androgens dehydroepiandrosterone, dehydroepiandrosterone sulfate, androstenedione, 5-androstenediol and 11β-hydroxy-androstenedione have a wide spectrum of important physiological effects. Aim of our study was to find differences in reaction of the C19 Δ5-steroids between healthy women and patients with adrenal insufficiency in various doses of Synacthen (1 ug, 10 ug and 250 ug). Our study involved seven healthy women and six premenopausal females (BMI an...

ea0056p43 | Adrenal cortex (to include Cushing's) | ECE2018

Non-classical form of congenital adrenal hyperplasia in patients with bilateral incidentalomas – hormonal and genetic analysis

Przybylik-Mazurek Elwira , Kurzynska Anna , Skalniak Anna , Hubalewska-Dydejczyk Alicja

Incidentalomas of adrenal glands are found in approximately 0.4–4.4% of abdominal CT-scan examinations and some of them can be caused by congenital adrenal hyperplasia (CAH). Bilateral masses can be detected in 10–15% of cases. CAH is one of the most common autosomal recessively inherited disorders. Non-classical form of congenital adrenal hyperplasia (NCCAH), is the milder form of the 21-hydroxylase deficiency, with the estimated incidence of 1:1000 worldwide.<p...

ea0056p44 | Adrenal cortex (to include Cushing's) | ECE2018

Adrenal insufficiency in treated PMR: The tip of the iceberg

Sagar Rebecca , Abbas Afroze

Background: Prolonged, high dose glucocorticoid therapy is used in to treat a number of rheumatological diseases, including polymyalgia rheumatica (PMR), giant-cell arteritis (GCA) and large vessel vasculitis (LVV). However there can be significant consequences of long-term glucocorticoid use, including iatrogenic adrenal insufficiency, due to suppression of the hypothalamic-pituitary-adrenal axis. This study aims to evaluate the prevalence, investigation and recovery of iatro...

ea0056p45 | Adrenal cortex (to include Cushing's) | ECE2018

Decreased quality of life in male patients with primary adrenal insufficiency of Indian origin

Bhatia Eesh , Singh Mahaveer

Background: In contrast to patients of European origin, primary adrenal insufficiency (PAI) in Indians is more common in males and often results from infectious etiologies (tuberculosis, Histoplasmosis). Most patients are treated with prednisolone, rather than hydrocortisone (HCT). A poor quality of life (QOL) has been reported in European patients with AD, but not in other populations. A few studies have also reported a high frequency of hypogonadism in PAI.<p class="abst...

ea0056p46 | Adrenal cortex (to include Cushing's) | ECE2018

The measurement of the renin–angiotensin–aldosterone system in patients with adrenal tumors with arterial hypertension

Romanova Natalia , Platonova Nadezhda , Molashenko Natalia , Nikankina Larisa , Troshina Ekaterina

Introduction: This problem has a major social and medical significance. The prevalence of secondary endocrine hypertension is around 40%, of which primary aldosteronism is up to 15% and is usually developed at working age. Despite of improvement of diagnostical two-step method of finding primary aldosteronism, none of these test results can be considered reliable because of false positive and false negative results. That’s why the problem of endocrine hypertension diagnos...

ea0056p47 | Adrenal cortex (to include Cushing's) | ECE2018

The renin-angiotensin-aldosteron system in primary adrenal insufficiency

Wolf Peter , Mayr Johanna , Poglitsch Marko , Gessl Alois , Luger Anton , Winhofer Yvonne , Krebs Michael

Background: Despite adequate hormone replacement therapy, evidence suggests that mortality is increased in patients suffering from primary adrenal insufficiency (AI), mainly because of cardiovascular diseases. Since activation of the renin-angiotensin-aldosteron system (RAAS) plays an important role in the development of hypertension and cardiovascular disease we aimed to investigate, if there are differences in AI compared to healthy controls.Methods: E...

ea0056p48 | Adrenal cortex (to include Cushing's) | ECE2018

Percutaneous microwave ablation of adrenal remnant tissue. A novel treatment modality for persistent Cushing’s disease

Ramli Rozana , Almazrouei Raya , Hameed Saira , Wernig Florian , Sam Amir , Leen Edward , Palazzo Fausto , Mendoza Nigel , Hatfield Emma , Martin Niamh , Meeran Karim

A 29-year-old lady presented with features of Cushing’s syndrome in October 2014. Investigations confirmed ACTH–dependent Cushing’s syndrome. An MRI scan showed a 4.5 mm right-sided pituitary lesion and subsequent inferior petrosal sinus sampling confirmed a central source of ACTH hypersecretion. She underwent trans-sphenoidal pituitary surgery in January 2015. Histology confirmed a corticotroph adenoma with a Ki-67 proliferation index of 1%. However, a mean cor...

ea0056p49 | Adrenal cortex (to include Cushing's) | ECE2018

Risk estimator for autonomous cortisol secretion in adrenal incidentalomas. Retrospective study of 100 cases

Castro Marta Araujo , Nunez Miguel Sampedro , Gonzalez Elena Fernandez , Moreno Nerea Aguire , Azpiroz Monica Marazuela

Purpose: A combined model of clinical, biochemical and radiological variables could help to predict autonomous cortisol secretion (ACS) in adrenal incidentalomas (AI).Methods: We analyzed retrospectively 100 patients diagnosed of AI between 2011 and 2015. AI was defined as an adrenal mass>1 cm, accidentally discovered by radiologic examination. ACS was ruled out (ACS-) by serum cortisol post-dexamethasone suppression test (Nugent) <3 μg/dl, ...

ea0056p50 | Adrenal cortex (to include Cushing's) | ECE2018

Is the adrenal vein sampling the gold standard diagnostic test for the subtyping of primary aldosteronism?

Portilla Ana Jimenez , Ribas Elena Mena , Bennasar Antonia Barcelo , Ruitort Juan Manuel Martinez , Segurola Cristina Alvarez , Font Mercedes Noval , Barcelo Carlos Antich , Soler Guillermo Serra , Jimenez Inaki Arguelles , Povedano Santiago Tofe , Macazaga Vicente Pereg

Introduction: Primary aldosteronism (PA) is the most common cause of secondary hypertension (5–10%) and it is underdiagnosed. Less than 50% of patients with PA have hypokalemia. The tests for determinate subtype of PA are cross-sectional imaging (adrenal CT or MRI) and adrenal vein sampling (AVS). The AVS seems to be important to direct appropriate therapy and surgery is the preferred treatment for patients with unilateral disease.Material and metho...

ea0056p51 | Adrenal cortex (to include Cushing's) | ECE2018

A descriptive study of patients with adrenocortical carcinoma treated in hospital clinico san carlos (HCSC) over the last 20 years

Barrio Elvira , Ramos Elvira , Miguel Paz de , Diaz J. Angel , Sanabria Concepcion , Cuesta Martin , Jimenez Ines , Espinosa Patricia , Garcia Antonio , Molino Angel

Introduction: Adrenocortical carcinoma (ACC) is a rare and aggressive tumor that accounts for 0.2% of cancer-related deaths. Case series and prospective studies are very limited due to its low prevalence. Current knowledge is based primarily on the opinions of experts in specialized units. The aim of this study is to perform a descriptive analysis of the management and prognosis of patients with ACC in HCSC in the last 20 years.Material and methods: Eigh...

ea0056p52 | Adrenal cortex (to include Cushing's) | ECE2018

Bilateral adrenalectomy for occult ectopic Cushing’s syndrome in two patients with catastrophic hypercortisolism

Topaloglu Oya , Bestepe Nagihan , Yalcin Bulent , Kilic Mehmet , Metin Melike Rusen , Ucmak Gulin , Ersoy Reyhan , Cakir Bekir

Introduction: Ectopic adrenocorticotropic hormone (ACTH) secretion is a less common cause of Cushing syndrome(CS) and is seen in 5 to 10% of patients with endogenous hypercortisolism. The most common types are bronchial carcinoids and small cell lung carcinoma. However, in approximately 10–20% of the cases, overt tumor cannot be found. Here, we described two patients with catastrophic hypercorticolism associated with ectopic CS and who were treated with bilateral adrenale...

ea0056p53 | Adrenal cortex (to include Cushing's) | ECE2018

In vitro effects of KCNJ5 mutations on cellular death mechanisms

Prada Elke Tatjana Aristizabal , Gomez-Sanchez Celso E , Reincke Martin , Williams Tracy A

Introduction: Primary aldosteronism (PA) is the most frequent form of endocrine hypertension and is commonly caused by an aldosterone producing adenoma (APA). Germline and somatic mutations in the KCNJ5 gene have been found in up to 40% of APAs and demonstrated to play a crucial role in the pathophysiology of PA.Aim: Here we characterize and investigate the effects of the most common KCNJ5 mutations on cellular death mechanisms based on...

ea0056p54 | Adrenal cortex (to include Cushing's) | ECE2018

The role of DHEAS in the diagnosis of possible autonomous cortisol secretion by incidentally discovered adrenal adenomas

Minnetti Marianna , Sbardella Emilia , Giorgio Maria Rosaria DI , Rizza Laura , Giannetta Elisa , Pofi Riccardo , Graziadio Chiara , Dato Carla Di , Lenzi Andrea , Isidori Andrea M

Introduction: Although possible autonomous cortisol secretion (pACS) is the commonest endocrine dysfunction detected in patients with adrenal incidentalomas, the diagnosis of this condition is still challenging. Dehydroepiandrosterone sulfate (DHEAS) is an adrenal androgen secreted by adrenal glands under the regulation of ACTH. DHEAS does not follow a circadian rhythm and has a long half-life in serum. Because of these features, low blood concentration of DHEAS has been recen...

ea0056p55 | Adrenal cortex (to include Cushing's) | ECE2018

Abnormal salivary cortisol result in patient with low probability of Cushing disease

Ahmed Ali , Shah Najeeb , Mohammed Kamrudeen

We presenting a case of 26 old lady who is known to have Denys-Drash syndrome, epilepsy and bronchial asthma who presented with history of recent significant weight gain, extensive abdominal bruising and significant muscle weakness which she described literally as not able to use her upper limbs to move to help shuffle her bottom in the floor, a manoeuvre that she was able to do before. Patient is on Carbamazepine, sodium valporate, levetiracetam , salbutamol and Pulmicort inh...

ea0056p56 | Adrenal cortex (to include Cushing's) | ECE2018

Improved salivary cortisol rhythm with dual-release hydrocortisone

Ceccato Filippo , Selmin Elisa , Sabbadin Chiara , Costa Miriam Dalla , Antonelli Giorgia , Plebani Mario , Barbot Mattia , Betterle Corrado , Boscaro Marco , Scaroni Carla

Introduction and aim: The purpose of replacement therapy in Adrenal Insufficiency (AI) is mimicking endogenous cortisol levels as closely as possible: dual release hydrocortisone (DR-HC) has been introduced to replicate the circadian cortisol rhythm. Multiple daily saliva collections could be used to assess the cortisol concentration during real-life: our aim was to study the salivary cortisol rhythm in AI.Materials and methods: We prospectively evaluate...

ea0056p57 | Adrenal cortex (to include Cushing's) | ECE2018

A case of adrenal Cushing’s syndrome initially presenting with diabetic ketoacidosis

Nogueira Edson , Muralidhara Koteshwara , Rahman Mushtaqur , Darko Daniel , Seechurn Shivshankar

A 49-year-old female was admitted to medical HDU with diabetes ketoacidosis (DKA) and newly diagnosed diabetes. Six months previously she was diagnosed with malignant hypertension. She had poorly controlled blood pressure despite treatment with four anti-hypertensives, which were her only regular medication. She had never used any medications or creams containing glucocorticoids. She had no history of hypokalaemia and reported no use of liquorice. She recently attended an outp...

ea0056p58 | Adrenal cortex (to include Cushing's) | ECE2018

The diagnostic accuracy of increased late night salivary cortisol for Cushing’s Syndrome: a real-life prospective study

Ceccato Filippo , Marcelli Giorgia , Martino Marianna , Concettoni Carolina , Brugia Marina , Trementino Laura , Michetti Grazia , Arnaldi Giorgio

Introduction and aim: A prompt diagnosis of Cushing’s Syndrome (CS) in high-risk populations is mandatory: 1-mg dexamethasone suppression test (1-mg DST); late night salivary cortisol (LNSC) and urinary free cortisol (UFC) are recommend, despite thresholds calculated in retrospective studies. Our aim was to study the diagnostic accuracy of LNSC measured with chemiluminescence assay in a prospective study, confirming discrepancies with mass spectrometry (MS).<p class="...

ea0056p59 | Adrenal cortex (to include Cushing's) | ECE2018

Cardiovascular features of possible autonomous cortisol secretion in patients with adrenal incidentalomas

Sbardella Emilia , Minnetti Marianna , D'Aluisio Denise , Rizza Laura , Di Giorgio Maria Rosaria , Pofi Riccardo , Giannetta Elisa , Vestri Annarita , Venneri Mary Anna , Morelli Sergio , Lenzi Andrea , Isidori Andrea M

Introduction: Low-grade incomplete post-dexamethasone cortisol suppression in patients with adrenal incidentalomas, recently redefined as possible autonomous cortisol secretion (pACS), has been associated with increased cardiovascular events and mortality. However, prospective studies documenting cardiac abnormalities in these patients are lacking.Methods: In the context of ERGO trial NIH (NCT02611258), between July 2016 and September 2017, 71 consecutiv...

ea0056p60 | Adrenal cortex (to include Cushing's) | ECE2018

Expert patients are better prepared to survive adrenal crisis than most – but still lack training in injection method

White Katherine , Yeoh Phillip

We examined online questionnaire responses received Dec 2017 – Jan 2018 from a sample of well-informed adrenal patients belonging to the Addison’s Disease Self-Help Group (N=374). ADSHG members reported levels of preparedness to self-manage during adrenal emergencies that were strikingly higher than any UK clinic survey.• 88% reported wearing medical jewellery• 80% had an in-date injection kit with them at the t...

ea0056p61 | Adrenal cortex (to include Cushing's) | ECE2018

Histopathological characteristics of lipid-poor adrenal adenomas

Vicennati Valentina , Casadio Elena , De Leo Antonio , Mosconi Cristina , Nanni Cristina , Selva Saverio , Zavatta Guido , Rinaldi Eleonora , Pagotto Uberto , Santini Donatella , Di Dalmazi Guido

Background: Up to 30% of incidentally-discovered adrenal masses are lipid-poor adenomas (LPA). The clinical significance of LPA is poorly understood. The aim of the study was to investigate histopathological features of LPA and their association with radiological parameters.Methods: A total of 39 patients with radiological evidence of LPA were included. LPA was defined as an adrenal mass with pre-contrast Hounsfield units (HU) ≧10, associated wit...

ea0056p62 | Adrenal cortex (to include Cushing's) | ECE2018

Different biological and functional features in patients with Cushing’s disease harboring micro- or macro-adenomas

Ceccato Filippo , Martino Marianna , Pinelli Silvia , Trementino Laura , Barbot Mattia , Boscaro Marco , Arnaldi Giorgio , Scaroni Carla

Background: ACTH-secreting pituitary adenomas represent two-thirds of Cushing’s syndrome (CS), the so-called Cushing’s disease (CD). These tumors are sometimes >10 mm in maximal diameter (macro-CD), but the majority of them are <10 mm (micro-CD). The aim of this study was to compare baseline characteristics of patients with micro-CD and macro-CD.Materials and methods: Clinical, hormonal and radiological data of 226 patients with CD were...

ea0056p63 | Adrenal cortex (to include Cushing's) | ECE2018

Salivary cortisol as a diagnostic tool for hypercortisolism in Cushing’s syndrome and adrenal incidentaloma

Ferreira Lia , Amaral Claudia , Palma Isabel , Cardoso Helena

Background: The lack of circadian rhythm is a marker of Cushing’s syndrome (CS). Therefore, salivary cortisol rhythm has been suggested for studies on the hypothalamic–pituitary–adrenal (HPA) axis. Late-night salivary cortisol has been used recently by many centers as a first line diagnostic test for CS, yet its accuracy is still on debate.Aim: To evaluated the performance of morning and late night salivary cortisol in patients with CS and...

ea0056p64 | Adrenal cortex (to include Cushing's) | ECE2018

Bilateral macronodular adrenal hyperplasia with autonomous cortisol secretion

Nogueira Claudia , Cunha Filipe , Souteiro Pedro , Oliveira Sofia Castro , Mesquita Joana

Introduction: Bilateral macronodular adrenal hyperplasia is a rare cause of Cushing’s syndrome (CS) characterized by multiple adrenal nodules >1 cm. It can be diagnosed in patients with overt CS but is more often diagnosed incidentally, especially in the 5th or 6th decades of life.Clinical case: 61-year-old woman with type 2 diabetes, arterial hypertension and dyslipidemia treated with metformin+sitagliptin 1000/50 mg bid, valsartan+hydrochlorot...

ea0056p65 | Adrenal cortex (to include Cushing's) | ECE2018

A systematic survey of low S-cortisol levels at the department of clinical chemistry: indications for testing and frequency of undiagnosed adrenal insufficiency

AEkerman Anna-Karin , Bartuseviciene Inga , Hoybye Charlotte , Bensing Sophie

A systematic survey of low S-cortisol levels at the department of clinical chemistry: indications for testing and frequency of undiagnosed adrenal insufficiency.Background: S-cortisol is frequently analyzed at clinical chemistry departments. Low levels of S-cortisol needs to be promptly acted on if the cause is undiagnosed adrenal insufficiency (AI). The causes of S-cortisol testing are however multiple and low levels are necessarily not alarming if foun...

ea0056p66 | Adrenal cortex (to include Cushing's) | ECE2018

Evaluation of cardiometabolic profile of patients submitted to unilateral adrenalectomy

Castro Raquel Vaz de , Costa Cristiana , Matos Tania , Quadros Catarina , Lopez Dolores , Vale Sonia do , Bugalho Maria Joao

Background and aims: It is known that unilateral adrenalectomy as treatment for autonomous secreting adrenal cortex adenomas effectively reduces cardiometabolic risk. Non-autonomous secreting adenomas are not expected to increase cardiometabolic risk, but this has not been thoroughly explored.We evaluated the blood pressure and glycemic profile before and after unilateral adrenalectomy for both autonomous and non-autonomous secreting adrenal cortex adenomas.<p class="abste...

ea0056p67 | Adrenal cortex (to include Cushing's) | ECE2018

Adrenal venous sampling in patients with ACTH-independent Cushing’s syndrome

Papakokkinou Eleni , Jakobsson Hugo , Sakinis Augustinas , Muth Andreas , Wangberg Bo , Ehn Olof , Johannsson Gudmundur , Ragnarsson Oskar

Background: ACTH-independent Cushing syndrome (CS) accounts for 15–20% of endogenous CS. Approximately 10% of these patients have bilateral adrenal lesions where the differential diagnoses are primary bilateral adrenal macronodular hyperplasia (PBMAH), primary pigmented nodular adrenal disease (PPNAD), bilateral cortisol producing adenomas or a unilateral cortisol producing adenoma with a contralateral nonfunctioning adenoma. Also, the prevalence of subclinical CS is high...

ea0056p68 | Adrenal cortex (to include Cushing's) | ECE2018

Association of the BclI glucocorticoid receptor polymorphism with metabolic parameters in female patients with adrenal incidentalomas

Ognjanovic Sanja , Antic Jadranka , Macut Djuro , Kovacevic Valentina Elezovic , Isailovic Tatjana , Popovic Bojana , Antic Ivana Bozic , Bogavac Tamara , Ilic Dusan , Petakov Milan , Damjanovic Svetozar

Interindividual variations in tissue sensitivity to glucocorticoids have been partly attributed to polymorphisms in the glucocorticoid receptor (GR) gene. The aim of this study was to investigate the prevalence of subclinical hypercortisolism (SH) in women with adrenal incidentaloma (AI), and whether BclI variant of the GR gene may contribute to metabolic abnormalities frequently present in these patients. We evaluated 106 women with AI. Anthropometric characteristics...

ea0056p69 | Adrenal cortex (to include Cushing's) | ECE2018

Adrenocortical carcinoma in the experience of one clinical center

Kurzynska Anna , Przybylik-Mazurek Elwira , Motyka Marcin , Hubalewska-Dydejczyk Alicja

Adrenocortical carcinoma (ACC) is a rare neoplasm with poor prognosis. Patients can present signs of hormone excess: virilisation, Cusging’s syndrome or only enlarged abdominal mass. Incidentally ACC can be also detected in the ultrasonography. Some of ‘non-hypersecretory’ ACCs can produce non-bioactive hormones steroid precursors or not very big amount of them and sometimes patients present subclinical Cushing’s symptoms. Surgery and adjuvant radiotherapy ...

ea0056p70 | Adrenal cortex (to include Cushing's) | ECE2018

Adrenocortical carcinoma: retrospective analysis of a series of clinical cases

Salas Jersy Jair Cardenas , Catalan Arturo Lisbona , Goiburu-Chenu Belen , Esteban-Rodriguez Maria Isabel , Regojo Rita Maria , Alvarez-Escola Cristina

Introduction: Adrenocortical carcinoma (ACC) is a rare and aggressive tumour. At diagnosis 21% has metastasis. Even after complete surgical removal, patients are at risk of recurrence as late as 10-12 years. The 5-year survival rate of Stage I to IV (ENSAT 2008) is 82%, 61%, 50% and 13% respectively.Objetive: To describe the epidemiological and clinical characteristics, as well as the evolution, treatments and overall survival of patients diagnosed with ...