Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056p611 | Steroid metabolism + action | ECE2018

Sex differences in glucocorticoid-induced metabolic disturbances in mice

Kaikaew Kasiphak , Steenbergen Jacobie , Kroon Jan , Meijer Onno C , Grefhorst Aldo , Visser Jenny A

Introduction: Glucocorticoids (GCs) are widely used anti-inflammatory medications that cause many metabolic side effects. Long-term treatment with GCs causes obesity and induces insulin resistance in many metabolic tissues, including adipose tissue and muscle. Factors secreted by adipose tissue, so-called adipokines, including leptin and adiponectin, also regulate the glucose-insulin axis. Obesity increases circulating leptin but decreases adiponectin levels. Despite several s...