Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056p160 | Steroid metabolism + action | ECE2018

Urinary steroid profile in patients with primary adrenal insufficiency under conventional glucocorticoid replacement: a case control study

Espiard Stephanie , McQueen Johanna , Ragnarsson Oskar , Bergthorsdottir Ragnhildur , Burman Pia , Dahlqvist Per , Ekman Bertil , Eden Engstrom Britt , Nilsson Anna G. , Skrtic Stanko , Wahlberg Jeanette , Sherlock Mark , Stewart Paul M. , Johannsson Gudmundur

Introduction: Primary adrenal insufficiency (PAI) leads to a drastically reduced production of steroids from the adrenal cortex, but a few patients may keep some residual adrenal steroid secretion that may simplify replacement therapy and prevent adrenal crisis. Irrespectively, the conventional glucocorticoid (GC) replacement therapy, using thrice-daily oral hydrocortisone, does not restore the patientsÂ’ physiological cortisol profile.Objective: The...

ea0056p161 | Steroid metabolism + action | ECE2018

Steroid profile using gas chromatography tandem mass spectrometry (GC-MS/MS) in search for a steroid which correlates most with subclinical hypercortisolism

Hana jr. Vaclav , Kosak Mikulas , Hana Vaclav , Hill Martin

Introduction: Gas chromatography tandem mass spectrometry (GC-MS/MS) quantitatively detects a large number of steroids at one time in a single serum sample. Most studies of subclinical hypercortisolism in adrenal incidentalomas have focused on detection of a few steroids like cortisol, DHEA/S, androstenedione, testosterone. We used GC-MS/MS to quantify 91 steroids in patients with adrenal incidentalomas to search for the most reliable marker of subclinical hypercortisolism.</p...